Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AmbTos808510 1-methyl-7H-purin-6-one

Synonyms: AG-K-73449, SureCN1992699, SureCN2115743, SureCN2115745, CHEBI:73959, ...

Buhl, L. et al., Dutta, S.P. et al., Hanski, C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC 57902

A human mesothelioma was heterotransplanted to nude mice, and the urinary excretions of hypoxanthine, xanthine, pseudouridine, orotic acid, 7-methylguanine, and 1-methylhypoxanthine have been followed before and after the tumor transplantation [1].

High impact information on NSC 57902

Sprague-Dawley rats bearing Yoshida Tumour showed an increased excretion of 7-methylguanine and 1-methylhypoxanthine with their urine as compared to control animals [2].
It is concluded that 1-methyladenosine is initially deaminated by adenosine deaminase to 1-methylinosine which is then cleaved by nucleoside phosphorylase to 1-methylhypoxanthine [3].

References

Urinary hypoxanthine and pseudouridine as indicators of tumor development in mesothelioma-transplanted nude mice. Buhl, L., Dragsholt, C., Svendsen, P., Hage, E., Buhl, M.R. Cancer Res. (1985) [Pubmed]
Increased concentration of 7-methylguanine and 1-methylhypoxanthine in urine of rats bearing Yoshida tumour. Hanski, C., Stehlik, G. Cancer Lett. (1980) [Pubmed]
Metabolism of 1-methyladenosine. Dutta, S.P., Chheda, G.B. Biochem. Med. Metab. Biol. (1987) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share