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Chemical Compound Review

CHEBI:19065     9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: HMDB02721, AC1L22KY, m(1)i, 2140-73-0, 1-Methylinosine, ...
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Disease relevance of 1-Methylinosine


High impact information on 1-Methylinosine


Biological context of 1-Methylinosine


Associations of 1-Methylinosine with other chemical compounds

  • These include the pre and posttreatment measurements of CEA, spermine, N2, N2-dimethylguanosine and 1-methylinosine, as well as two ratios of the polyamines and three ratios of the nucleosides in the post-treatment of the polyamines and three ratios of the nucleosides in the post-treatment measurements [7].
  • It was found that approximately 57% of 1-[methyl-8-14C] adenosine administered iv was excreted unchanged in the urine and 33% of the excreted radioactivity in the urine was associated with the major metabolite 1-methyl-hypoxanthine and about 4.5% was associated with 1-methylinosine [10].

Gene context of 1-Methylinosine


Analytical, diagnostic and therapeutic context of 1-Methylinosine


  1. Altered excretion of modified nucleosides and beta-aminoisobutyric acid in subjects with acquired immunodeficiency syndrome or at risk for acquired immunodeficiency syndrome. Borek, E., Sharma, O.K., Buschman, F.L., Cohn, D.L., Penley, K.A., Judson, F.N., Dobozin, B.S., Horsburgh, C.R., Kirkpatrick, C.H. Cancer Res. (1986) [Pubmed]
  2. Nucleoside excretion in breast cancer: comparison with other biochemical tumour-index-substances. Coombes, R.C., Powles, T.J., Gehrke, C.W., Waalkes, T.P., Neville, A.M. Investigative & cell pathology. (1979) [Pubmed]
  3. Relationship of urinary excretion of modified nucleosides to disease status in childhood acute lymphoblastic leukemia. Heldman, D.A., Grever, M.R., Miser, J.S., Trewyn, R.W. J. Natl. Cancer Inst. (1983) [Pubmed]
  4. RNA metabolism in uremic patients: accumulation of modified ribonucleosides in uremic serum. Technical note. Niwa, T., Takeda, N., Yoshizumi, H. Kidney Int. (1998) [Pubmed]
  5. Biological markers and small cell carcinoma of the lung: a clinical evaluation of urinary ribonucleosides. Waalkes, T.P., Abeloff, M.D., Ettinger, D.S., Woo, K.B., Gehrke, C.W., Kuo, K.C., Borek, E. Cancer (1982) [Pubmed]
  6. High performance liquid chromatographic determination of serum UV profiles of normal subjects and patients with breast cancer and benign fibrocystic changes. Krstulovic, A.M., Hartwick, R.A., Brown, P.R. Clin. Chim. Acta (1979) [Pubmed]
  7. A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast. Woo, K.B., Waalkes, T.P., Ahmann, D.L., Tormey, D.C., Gehrke, C.W., Oliverio, V.T. Cancer (1978) [Pubmed]
  8. The urinary excretion of the nucleosides pseudouridine and 1-methylinosine during normal menstrual cycle. Lehtiö, H., Mäenpää, P.H. Clin. Chim. Acta (1977) [Pubmed]
  9. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. Tebib, J.G., Reynaud, C., Cedoz, J.P., Letroublon, M.C., Niveleau, A. Br. J. Rheumatol. (1997) [Pubmed]
  10. Metabolism of 1-methyladenosine. Dutta, S.P., Chheda, G.B. Biochem. Med. Metab. Biol. (1987) [Pubmed]
  11. Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides. Tormey, D.C., Waalkes, T.P., Ahmann, D., Gehrke, C.W., Zumwatt, R.W., Snyder, J., Hansen, H. Cancer (1975) [Pubmed]
  12. An enzyme-linked immunosorbent assay (ELISA) for the detection and quantitation of the tumor marker 1-methylinosine in human urine. D'Ambrosio, S.M., Gibson-D'Ambrosio, R.E., Trewyn, R.W. Clin. Chim. Acta (1991) [Pubmed]
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