High impact information on Paverine

• Circulatory assistance was instituted by means of femoro-femoral bypass with a roller pump and a hollow-fiber oxygenator; inotropic drugs and drugs aimed at reducing pulmonary vascular resistance (nitroprusside, moxaverine, and isoproterenol) were also given [1].
• Using a combination of novel techniques to assess quantitatively the shape and the filterability of red blood cells (RBC) after exposure to stress conditions (400 mosmol/l, lactacidosis, pH 6.8), the effects of 1-benzyl-3-ethyl-6,7-dimethoxy-isoquinoline hydrochloride (moxaverine-HCl, Kollateral) were tested [2].
• The LPC induced a hitherto not identified metabolic process within the erythrocyte which depended on various factors as the Ca++-concentration, pH-value, and temperature of the suspending medium and which was advanced by guanosine or certain drugs as for instance moxaverine, a derivative of papaverine [3].

Analytical, diagnostic and therapeutic context of Paverine

• Stable normothermic (37 degrees C) perfusion conditions were maintained at a constant perfusion pressure in the range of 40-60 mm Hg by administration of the spasmo lytic moxaverine (0.5 mg/mL of perfusate as initial dose) at a perfusate flow rate of 0.5 mL/min for 60 min [4].

References