Disease relevance of Fenotiazina

• A closely related phenthiazine antipsychotic, trifluoperazine, which does not bind to nucleic acids, did not reduce scrapie infectivity [1].
• Dietary PT did not alter the toxicity of SJ but did cause reductions in feed intake and average daily gain [2].

High impact information on Fenotiazina

• The assay for measuring lipid peroxidation products in serum utilizes the ability of lipid hydroperoxides to generate methylene blue from 10N-methylcarbamyl 3,7-dimethylamino 10H-phenothiazine [3].
• Synthetic antioxidant potassium phenosan in ultralow doses administrated in combination with antitumor antibiotic adriamycin in a therapeutic dose (8 mg/kg) markedly prolonged the mean life span of tumor-bearing animals compared to adriamycin monotherapy [4].
• Boc-L-Lysine derivatives and lysine-containing peptides bearing the electron donor 10H-phenothiazine (PTZ) or the redox chromophore tris(2,2'-bipyridine)ruthenium(II) dication ([Rub3]2+, where b is 2,2'-bipyridine) have been synthesized and characterized [5].
• Phenothiazine (thiodiphenylamine) in commercial pesticide formulations is analyzed by high-speed liquid chromatography and ultraviolet absorption detection [6].

Chemical compound and disease context of Fenotiazina

• Sensitivity of membrane-associated scrapie infectivity to inactivation by u.v. irradiation could be increased by addition of chlorpromazine, a phenthiazine antipsychotic which penetrates lipid bilayers and induces single-strand breaks in nucleic acids under irradiation [1].

Associations of Fenotiazina with other chemical compounds

• The effects of natural lipid-soluble antioxidant, alpha-tocopherol (alpha-TP), and the synthetic water-soluble antioxidant, phenosan potassium salt (Ph-K), in a broad range of concentrations down to ultralow doses (10(-4)-10(-20) M) on the activity of protein kinase C (PKC) have been studied [7].

Gene context of Fenotiazina

• This effect depended on the dose of antioxidant and was maximum at phenosan concentrations of 10(-17) and 10(-15) M [4].

References