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Chemical Compound Review

Agrazine     10H-phenothiazine

Synonyms: Antiverm, Fenoverm, Nemazene, Nemazine, Nexarbol, ...
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Disease relevance of Fenotiazina

  • A closely related phenthiazine antipsychotic, trifluoperazine, which does not bind to nucleic acids, did not reduce scrapie infectivity [1].
  • Dietary PT did not alter the toxicity of SJ but did cause reductions in feed intake and average daily gain [2].

High impact information on Fenotiazina


Chemical compound and disease context of Fenotiazina

  • Sensitivity of membrane-associated scrapie infectivity to inactivation by u.v. irradiation could be increased by addition of chlorpromazine, a phenthiazine antipsychotic which penetrates lipid bilayers and induces single-strand breaks in nucleic acids under irradiation [1].

Associations of Fenotiazina with other chemical compounds

  • The effects of natural lipid-soluble antioxidant, alpha-tocopherol (alpha-TP), and the synthetic water-soluble antioxidant, phenosan potassium salt (Ph-K), in a broad range of concentrations down to ultralow doses (10(-4)-10(-20) M) on the activity of protein kinase C (PKC) have been studied [7].

Gene context of Fenotiazina

  • This effect depended on the dose of antioxidant and was maximum at phenosan concentrations of 10(-17) and 10(-15) M [4].


  1. Inactivation of the scrapie agent by ultraviolet irradiation in the presence of chlorpromazine. Dees, C., Wade, W.F., German, T.L., Marsh, R.F. J. Gen. Virol. (1985) [Pubmed]
  2. Effects of microsomal enzyme induction on the toxicity of pyrrolizidine (Senecio) alkaloids. White, R.D., Swick, R.A., Cheeke, P.R. Journal of toxicology and environmental health. (1983) [Pubmed]
  3. Decreased total antioxidant capacity but normal lipid hydroperoxide concentrations in sera of critically ill patients. Dasgupta, A., Malhotra, D., Levy, H., Marcadis, D., Blackwell, W., Johnston, D. Life Sci. (1997) [Pubmed]
  4. Modification of chemotherapeutic activity in adriablastine with the synthetic antioxidant in low doses. Pal'mina, N.P., Gaintseva, V.D., Burlakova, Y.B. Bull. Exp. Biol. Med. (2003) [Pubmed]
  5. Synthesis of redox derivatives of lysine and related peptides containing phenothiazine or tris(2,2'-bipyridine)ruthenium(II). Peek, B.M., Ross, G.T., Edwards, S.W., Meyer, G.J., Meyer, T.J., Erickson, B.W. Int. J. Pept. Protein Res. (1991) [Pubmed]
  6. High-speed liquid chromatographic determination of phenothiazine in commercial pesticide formulations. Byrne, M. Journal - Association of Official Analytical Chemists. (1976) [Pubmed]
  7. Natural (alpha-tocopherol) and synthetic (phenosan potassium salt) antioxidants regulate the protein kinase C activity in a broad concentration range (10(-4)-10(-20) M). Maltseva, E.L., Palmina, N.P., Burlakova, E.B. Membrane & cell biology. (1998) [Pubmed]
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