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Chemical Compound Review

Amenide     [1-(2,2-dichloroethanoyl)- 3,4-dihydro-2H...

Synonyms: Amenox, Quinfamide, Quinfamido, Quinfamidum, Amenide (TN), ...
 
 
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Disease relevance of Amenide

 

High impact information on Amenide

  • Phagocytosis of quinfamide particles by Entamoeba histolytica [3].
  • This paper describes a high-performance liquid chromatographic method for the assay of quinfamide and its main metabolite, 1-(dichloroacetyl)-1,2,3,4,-tetrahydro-6-quinolinol, in plasma, urine and feces [4].
  • The major pathways of quinfamide metabolism in the rat involve hydrolysis of one or both ester groups, acetylation of the de-acylated product to 1-acetyl-1, 2, 3, 4-tetrahydro-6-quinolinol, oxidation of this to the 1-glycolyl metabolite, and aromatization to 6-hydroxyquinoline [5].
 

Analytical, diagnostic and therapeutic context of Amenide

References

  1. A study with quinfamide in the treatment of chronic amebiasis in adults. Guevara, L., Garcia Tsao, G., Uscanga, L.F. Clinical therapeutics. (1983) [Pubmed]
  2. Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Slighter, R.G., Yarinsky, A., Drobeck, H.P., Bailey, D.M. Parasitology (1980) [Pubmed]
  3. Phagocytosis of quinfamide particles by Entamoeba histolytica. Anaya-Velázquez, F., Morales-Fuentes, L. Arch. Med. Res. (2000) [Pubmed]
  4. Solid-phase extraction and liquid chromatographic quantitation of quinfamide in biological samples. Morales, J.M., Jung, C.H., Alarcón, A., Barreda, A. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  5. The disposition of quinfamide in the rat. Baker, J.F., O'Melia, P.E., Benziger, D.P., Clemans, S.D., Edelson, J. Archives internationales de pharmacodynamie et de thérapie. (1982) [Pubmed]
  6. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. Padilla, N., Diaz, R., Alarcon, A., Barreda, R. ScientificWorldJournal (2002) [Pubmed]
 
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