Disease relevance of Dysentery, Amebic

• To test the role of amoebic cysteine proteinases in the pathogenesis of amoebic colitis, human intestinal xenografts in SCID mice were infected with E. histolytica trophozoites expressing an antisense message to ehcp5 [1].
• The sensitivity of these assays was evaluated with sera from 27 patients with radiologically proven, cellulose acetate precipitation (CAP) test-positive amebic liver abscess, 7 patients with parasitologically and PCR-proven amebic colitis, and 11 patients with parasitologically and PCR-proven E. histolytica cyst passage [2].
• Thus, paromomycin is an effective alternative to conventional multi-drug therapy for intestinal amebiasis, and it has the advantages of low toxicity, brief duration of therapy, and a high rate of patient compliance [3].
• The diagnosis of amoebic colitis and amoebic perforation of the bowel were difficult and therefore all patients with 'acute abdomen' had proctosigmoidoscopy and a trial of metronidazole for 24-48 h before laparotomy [4].
• Tinidazole, a recent derivative of the nitroimidazole group of compounds, was able to achieve a cure in 96% of children with acute amebic dysentery when given in three single daily doses of approximately 60 mg/kg of body weight [5].

High impact information on Dysentery, Amebic

• Metronidazole has the advantage of effectiveness against intestinal amoebiasis and the probability of cure with a shorter course of treatment [6].
• We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of amebic colitis [7].
• Humoral and mucosal IgA antibody response to a recombinant 52-kDa cysteine-rich portion of the Entamoeba histolytica galactose-inhibitable lectin correlates with detection of native 170-kDa lectin antigen in serum of patients with amebic colitis [8].
• Treatment of symptomatic intestinal amoebiasis with tinidazole [9].
• Paromomycin in the treatment of mild-to-moderate intestinal amebiasis [10].

Chemical compound and disease context of Dysentery, Amebic

• These results demonstrate for the first time that amoebic cysteine proteinases are a key virulence factor in amoebic colitis, and provide a novel mechanism for their activity [1].
• These results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice and suggest a protective role for fecal anti-lectin IgA in vivo [11].
• Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis [12].
• Quinfamide, a luminal amebicide, is a dichloroacetyl quinolol used to treat chronic and subacute intestinal amebiasis [13].
• Short-term treatment of acute intestinal amoebiasis with ornidazole [14].

Anatomical context of Dysentery, Amebic

• The presence of integrin-dependent binding may allow trophozoites to opportunistically adhere to activated intestinal epithelium or vascular endothelium expressing ICAM-1 during amebic colitis or hepatic abscess [15].

Gene context of Dysentery, Amebic

• Of eigh t sera from patients with intestinal amebiasis, five were positive immediately and seven within 24 hours [16].
• A new isoform of the serine-rich E. histolytica protein recognized by human secretory IgA antibodies from patients with intestinal amebiasis [17].
• Symptomatic amebic colitis was easily treated and good results were obtained even with the extremely diminished CD4 count [18].
• Flagyl (Metronidazole) in the treatment of intestinal amebiasis. Part IV [19].
• Letter: Alpha-fetoprotein in amoebic colitis and liver abscess [20].

Analytical, diagnostic and therapeutic context of Dysentery, Amebic

• Western blot of Entamoeba histolytica antigenic fractions: reactivity analysis with sera from intestinal amoebiasis patients [21].
• HL 707, Liroldine, a novel synthetic compound, was found effective against both extraintestinal and intestinal amoebiasis in animal models [22].
• When analysing the sera from patients with intestinal amoebiasis, 10% of them were positive by ELISA but non by CIE [23].

References