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Chemical Compound Review

Dolcuran     ethyl 5,10-dimethyl-2-oxo-1-aza-5...

Synonyms: Probonal, Rimagina, Probon, Rimazolium, CHEMBL263807, ...
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Disease relevance of Rimazolium Metilsulfate

  • The reduced toxicity of indomethacin in combination with Probon is probably due to a change in metabolism produced by the hepatic microsomal enzyme inducer, Probon [1].
  • Analgesic effect of Probon in heart diseases [2].
  • Observations with Probon in the treatment of coxarthroses [3].
  • In patients with chronic intractable pain, a combination of azidomorphine (0.5 mg) and Probon (150 mg) achieved total pain relief without noticeable euphoria and none of the patients subjected to nalorphine-precipitation showed signs of abstinence according to the Himmelsbach scoring system [4].

High impact information on Rimazolium Metilsulfate


  1. Investigation of the interaction between Probon and indomethacin in rats. Sebestyén, G., Gergely, V., Virág, S., Mészáros, Z. Journal of applied toxicology : JAT. (1983) [Pubmed]
  2. Analgesic effect of Probon in heart diseases. Tóth, K., Székely, A., Antalóczy, Z. Therapia Hungarica (English edition) (1980) [Pubmed]
  3. Observations with Probon in the treatment of coxarthroses. Zbojanová, M., Tauchmannová, H., Trnavsky, K. Therapia Hungarica (English edition) (1978) [Pubmed]
  4. Azidomorphines and homopyrimidazols: a new approach to the ideal analgetic. Knoll, J. Acta physiologica et pharmacologica Bulgarica. (1977) [Pubmed]
  5. The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system. Magyar, K., Härsing, L.G., Tekes, K., Knoll, J. Arch. Toxicol. Suppl. (1980) [Pubmed]
  6. Analgesic effect of probon in traumatology. Kalabay, L. Therapia Hungarica (English edition) (1978) [Pubmed]
  7. The application of probon, a new analgesic in thoracic surgery. Kiss, J., Bacsa, S. Therapia Hungarica (English edition) (1976) [Pubmed]
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