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Chemical Compound Review:

Dolcuran ethyl 5,10-dimethyl-2-oxo-1-aza-5...

Synonyms: Probonal, Rimagina, Probon, Rimazolium, CHEMBL263807, ...

This record was replaced with 71940.

Knoll, J., Sebestyén, G. et al., Magyar, K. et al., Kiss, J. et al., Zbojanová, M. et al., et al.

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Disease relevance of Rimazolium Metilsulfate

The reduced toxicity of indomethacin in combination with Probon is probably due to a change in metabolism produced by the hepatic microsomal enzyme inducer, Probon [1].
Analgesic effect of Probon in heart diseases [2].
Observations with Probon in the treatment of coxarthroses [3].
In patients with chronic intractable pain, a combination of azidomorphine (0.5 mg) and Probon (150 mg) achieved total pain relief without noticeable euphoria and none of the patients subjected to nalorphine-precipitation showed signs of abstinence according to the Himmelsbach scoring system [4].

High impact information on Rimazolium Metilsulfate

In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes [5].
Analgesic effect of probon in traumatology [6].
The application of probon, a new analgesic in thoracic surgery [7].

References

Investigation of the interaction between Probon and indomethacin in rats. Sebestyén, G., Gergely, V., Virág, S., Mészáros, Z. Journal of applied toxicology : JAT. (1983) [Pubmed]
Analgesic effect of Probon in heart diseases. Tóth, K., Székely, A., Antalóczy, Z. Therapia Hungarica (English edition) (1980) [Pubmed]
Observations with Probon in the treatment of coxarthroses. Zbojanová, M., Tauchmannová, H., Trnavsky, K. Therapia Hungarica (English edition) (1978) [Pubmed]
Azidomorphines and homopyrimidazols: a new approach to the ideal analgetic. Knoll, J. Acta physiologica et pharmacologica Bulgarica. (1977) [Pubmed]
The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system. Magyar, K., Härsing, L.G., Tekes, K., Knoll, J. Arch. Toxicol. Suppl. (1980) [Pubmed]
Analgesic effect of probon in traumatology. Kalabay, L. Therapia Hungarica (English edition) (1978) [Pubmed]
The application of probon, a new analgesic in thoracic surgery. Kiss, J., Bacsa, S. Therapia Hungarica (English edition) (1976) [Pubmed]

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