Disease relevance of Pain, Intractable

• SUMMARY BACKGROUND DATA: Severe intractable pain is the most common indication for resection in chronic pancreatitis [1].
• We treated a patient with alcohol-induced cirrhosis, intractable pain from a defective hip prosthesis, and multiple red cell allo-antibodies with recombinant human erythropoietin (EPO) in order to facilitate collection of blood for autologous transfusion during an elective total hip revision [2].
• The patient had been on total parenteral nutrition for 17 mo, following extensive bowel resection for intractable pain, nausea, and vomiting caused by chronic idiopathic intestinal pseudoobstruction [3].
• Effective analgesia resulted from the injection of peridural meperidine in two groups of cancer patients, eight with postoperative pain and eight with intractable pain [4].
• Fifteen patients with breast cancer and skeletal metastases who had bone pain refractory to opioid analgesics and who were not eligible for or had not responded to local field radiotherapy, were treated with strontium-89 [5].

Psychiatry related information on Pain, Intractable

• Milnacipran for the drastic improvement of refractory pain in a patient without depressive symptoms: a case report [6].
• DESIGN: Four cases of phantom limb pain refractory to multiple treatment modalities were treated with oral methadone [7].

High impact information on Pain, Intractable

• The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by skeletal muscle spasm and tenderness [8].
• Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain [9].
• Acute response to intracisternal bupivacaine in patients with refractory pain of the head and neck [10].
• These results confirm that MCS can be a satisfactory and durable alternative to medical treatments in patients with refractory pain, and suggest that the efficacy of MCS may be predicted in the first month of therapy [11].
• Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain [12].

Chemical compound and disease context of Pain, Intractable

• Several clinical studies have shown oral morphine and methadone to be effective in the treatment of intractable pain in patients with malignant disease [13].
• The minimum effective analgetic blood concentration (MEAC) of pethidine following intravenous administration was identified in 3 patients with intractable pain [14].
• In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests [15].
• We have previously reported 10 patient histories involving various intractable pain syndromes where the administration of Haloperidol either eliminated the need for narcotic analgesics or resulted in a significant reduction in narcotic dosage [16].
• Intrathecal methyl prednisolone may be considered for intractable pain but efficacy and safety have not been confirmed [17].

Biological context of Pain, Intractable

• Clinical pharmacokinetics applied to patients with intractable pain: studies with pethidine [14].
• Bacteriology, drug stability and exchange of percutaneous delivery systems and antibacterial filters in long-term intrathecal infusion of opioid drugs and bupivacaine in "refractory" pain [18].
• Based on the Bi-Digital O-Ring Test localization method for specific substances or microbes, the author has successfully treated cases of chronic intractable pain by the combination of anti-viral or bacterial agents with either manual acupuncture, electro-acupuncture or transcutaneous electrical stimulation through a pair of surface electrodes [19].
• The authors describe the technique of Asleep-Awake-Asleep anesthesia for open dorsal rhizotomy in a 78-year-old female patient, admitted to the hospital with intractable pain in the distribution of C2 dermatome following a road traffic accident [20].

Anatomical context of Pain, Intractable

• A total of 11 patients with refractory pain secondary to autosomal dominant polycystic kidney disease underwent ultrasound guided percutaneous aspiration of cyst fluid on the affected side [21].
• Techniques for blocking the celiac plexus were evaluated by conventional posteroanterior and lateral x-rays and computed tomography (CT) in 20 patients with intractable pain due to carcinoma of the pancreas and by determining spread of injected dye at the time of autopsy in three corpses [22].
• We report herein the performance of a videothoracoscopic left splanchnicectomy in a patient with a previous right pneumonectomy who suffered intractable pain from an irresectable left adrenal metastasis associated with metastatic retroperitoneal lymph nodes [23].
• The emergence of intractable pain may notably be due to the activation of N-methyl-D-aspartate (NMDA) receptors located in the central nervous system [24].
• The role of mechanical stabilization via surgery is not as well delineated but should be considered in patients with intractable pain due to C1-C2 facet joint disease and those with progressive neurologic deficiencies [25].

Gene context of Pain, Intractable

• Several studies indicate that the refractory pain of metastatic cancer is related to the direct nociceptive effects ET-1 [26].
• RESULTS: Both patients experienced rapid, substantial, and sustained relief of chronic refractory pain at the treatment site after targeted administration of etanercept [27].
• The history of the Intractable Pain Society of Great Britain and Ireland [28].
• We argue that PG is the operation of choice to relieve intractable pain in most patients with chronic pancreatitis associated with duct dilatation [29].
• Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain [30].

Analytical, diagnostic and therapeutic context of Pain, Intractable

• Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine [31].
• Both patients' conditions responded to acyclovir, although one patient required amputation of a digit due to intractable pain [32].
• This retrospective study reports on the outcome of 17 patients with persistent cervical and lumbar pyogenic spondylitis who had one-stage combined surgery and fusion with use of a titanium mesh cage for intractable pain, kyphosis, and neurologic impairment [33].
• Phenol rhizotomy is indicated for the relief of intractable pain secondary to recurrent unresectable carcinoma of the rectum in carefully selected patients [34].
• Neurolytic nerve block, using either alcohol (A) or phenol (P), is frequently used to treat intractable pain [35].

References