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MeSH Review

Pain, Intractable

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Disease relevance of Pain, Intractable


Psychiatry related information on Pain, Intractable


High impact information on Pain, Intractable


Chemical compound and disease context of Pain, Intractable

  • Several clinical studies have shown oral morphine and methadone to be effective in the treatment of intractable pain in patients with malignant disease [13].
  • The minimum effective analgetic blood concentration (MEAC) of pethidine following intravenous administration was identified in 3 patients with intractable pain [14].
  • In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests [15].
  • We have previously reported 10 patient histories involving various intractable pain syndromes where the administration of Haloperidol either eliminated the need for narcotic analgesics or resulted in a significant reduction in narcotic dosage [16].
  • Intrathecal methyl prednisolone may be considered for intractable pain but efficacy and safety have not been confirmed [17].

Biological context of Pain, Intractable


Anatomical context of Pain, Intractable


Gene context of Pain, Intractable


Analytical, diagnostic and therapeutic context of Pain, Intractable


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  12. Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain. Perren, F., Buchser, E., Chédel, D., Hirt, L., Maeder, P., Vingerhoets, F. Pain (2004) [Pubmed]
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  17. Tolerability of treatments for postherpetic neuralgia. Douglas, M.W., Johnson, R.W., Cunningham, A.L. Drug safety : an international journal of medical toxicology and drug experience. (2004) [Pubmed]
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  23. Videothoracoscopic splanchnicectomy for intractable pain from adrenal metastasis. Lang-Lazdunski, L., Le Pimpec-Barthes, F., Riquet, M. Ann. Thorac. Surg. (2002) [Pubmed]
  24. Successful use of ketamine for intractable cancer pain. Lossignol, D.A., Obiols-Portis, M., Body, J.J. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. (2005) [Pubmed]
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  28. The history of the Intractable Pain Society of Great Britain and Ireland. Mehta, M. Pain (1980) [Pubmed]
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  34. Intrathecal phenol rhizotomy for management of pain in recurrent unresectable carcinoma of the rectum. Rodriguez-Bigas, M., Petrelli, N.J., Herrera, L., West, C. Surgery, gynecology & obstetrics. (1991) [Pubmed]
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