Disease relevance of Osteoarthritis, Hip

• The WOMAC Knee and Hip Osteoarthritis Indices: development, validation, globalization and influence on the development of the AUSCAN Hand Osteoarthritis Indices [1].
• We found consistently lower levels of IGF-I and IGFBP-3 and a tendency to higher levels of IGFBP-1 in the patients with hip fractures, who also had a lower total body mass, lower fat mass and bone mineral density than the coxarthrosis group, indicating a more catabolic state in the patients with hip fracture, even 6 months after the trauma [2].
• A 38-year-old woman on piroxicam for hip osteoarthritis secondary to hip dysplasia developed secondary sterility [3].
• Baseline hyaluronate levels and their increase during the first year of follow-up predicted radiographic changes in knee osteoarthritis, and baseline cartilage oligomeric matrix protein levels predicted radiological changes in hip osteoarthritis [4].

High impact information on Osteoarthritis, Hip

• Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females [5].
• OBJECTIVE: To examine the association of baseline concentrations of serum cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) with the development and progression of radiographic hip osteoarthritis (RHOA) in elderly women [6].
• Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study [7].
• Type I collagen alpha1 Sp1 transcription factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women [8].
• OBJECTIVE: To describe progression over 8 years in a community-based sample of elderly women with radiographic findings of hip osteoarthritis (RHOA) with or without hip pain [9].

Chemical compound and disease context of Osteoarthritis, Hip

• OBJECTIVE: To evaluate the ability of diacerein, an interleukin-1beta inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis (OA) [10].
• Ultrasound-guided steroid injections in the treatment of hip osteoarthritis: comment on the letter by Margules [11].
• Association of nitrate use with risk of new radiographic features of hip osteoarthritis in elderly white women: the study of osteoporotic fractures [12].
• OBJECTIVE: To estimate and compare the age- and sex-specific prevalence of radiographic hip osteoarthritis (RHOA) in a population-based study of the Pima Indians, using 3 atlas-based methods for assessing features of RHOA [13].
• Sulindac (cis-5-fluoro-2-methyl-l-[(p-methyl sulfinyl)-benzylidene]-indene-3-acetic acid) is a new nonsteroidal antirheumatic drug recently evaluated in a double-blind trial of 91 patients with hip osteoarthritis [14].

Biological context of Osteoarthritis, Hip

• The blood loss-reducing effect of desmopressin during dextran therapy was studied in a double-blind fashion in 79 elderly but otherwise healthy patients with preoperative normal bleeding time undergoing total hip replacement for primary coxarthrosis [15].

Anatomical context of Osteoarthritis, Hip

• We analyzed bone turnover markers (osteocalcin, bone ALP, beta-crosslaps-CTX) and cytokines (IL-1, IL-8 and IL-10) in hip joint fluid in 10 patients before revision surgery and in 39 with idiopathic coxarthrosis [16].
• Levels of chondroitin sulfate isomers in synovial fluid of patients with hip osteoarthritis [17].

Gene context of Osteoarthritis, Hip

• Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis [18].
• Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study [19].
• The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population [20].
• METHODS: A polyclonal rabbit antiserum to the amino-terminal peptide of human PTHrP was used to stain 10 interface membrane samples from loose THR and 10 synovial tissue samples from hip osteoarthritis (OA) [21].
• RECENT FINDINGS: A UK group reported an association of the FRZB gene with hip osteoarthritis in females [22].

Analytical, diagnostic and therapeutic context of Osteoarthritis, Hip

• Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis [23].
• Treatment of coxarthroses with intraarterial injection of No-Spa + Lidocaine [24].
• BACKGROUND: An open-label, randomised, multicentre study was carried out to compare the efficacy and tolerability of indomethacin capsules and ketoprofen controlled-release capsules in the symptomatic treatment of coxarthrosis [25].

References