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Chemical Compound Review

NSC-271     methanesulfonamide

Synonyms: NSC271, CHEMBL305268, AG-C-86132, ACMC-209hmq, ANW-27120, ...
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Disease relevance of methanesulfonamide

  • On the average, the dimethyl phosphoramidates are twice as dose potent as the corresponding methanesulfonamide (AMSA) compounds against P388 leukemia in vivo, but also show about twice the acute toxicity and no resultant improvement in tumor cell selectivity (ILSmax values) is seen [1].

High impact information on methanesulfonamide


Anatomical context of methanesulfonamide


Associations of methanesulfonamide with other chemical compounds


  1. Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine. Rewcastle, G.W., Atwell, G.J., Baguley, B.C., Denny, W.A. J. Med. Chem. (1984) [Pubmed]
  2. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Horiguchi, T., Snipes, J.A., Kis, B., Shimizu, K., Busija, D.W. Neuroscience (2006) [Pubmed]
  3. Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors. Singh, S.K., Vobbalareddy, S., Shivaramakrishna, S., Krishnamraju, A., Rajjak, S.A., Casturi, S.R., Akhila, V., Rao, Y.K. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  4. Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide. Lee, K., Park, J.B., Jeon, B.H., Kim, K.J., Ryu, P.D., Kwon, L.S., Kim, H.Y. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  5. Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Watanabe, M., Koike, H., Ishiba, T., Okada, T., Seo, S., Hirai, K. Bioorg. Med. Chem. (1997) [Pubmed]
  6. Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents. Krafte, D.S., Volberg, W.A. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  7. A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2). Huff, R., Collins, P., Kramer, S., Seibert, K., Koboldt, C., Gregory, S., Isakson, P. Inflamm. Res. (1995) [Pubmed]
  8. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Rosenstock, M., Danon, A., Rimon, G. Biochim. Biophys. Acta (1999) [Pubmed]
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