The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

NSC-271     methanesulfonamide

Synonyms: NSC271, CHEMBL305268, AG-C-86132, ACMC-209hmq, ANW-27120, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of methanesulfonamide

  • On the average, the dimethyl phosphoramidates are twice as dose potent as the corresponding methanesulfonamide (AMSA) compounds against P388 leukemia in vivo, but also show about twice the acute toxicity and no resultant improvement in tumor cell selectivity (ILSmax values) is seen [1].
 

High impact information on methanesulfonamide

 

Anatomical context of methanesulfonamide

 

Associations of methanesulfonamide with other chemical compounds

References

  1. Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine. Rewcastle, G.W., Atwell, G.J., Baguley, B.C., Denny, W.A. J. Med. Chem. (1984) [Pubmed]
  2. Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Horiguchi, T., Snipes, J.A., Kis, B., Shimizu, K., Busija, D.W. Neuroscience (2006) [Pubmed]
  3. Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors. Singh, S.K., Vobbalareddy, S., Shivaramakrishna, S., Krishnamraju, A., Rajjak, S.A., Casturi, S.R., Akhila, V., Rao, Y.K. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  4. Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide. Lee, K., Park, J.B., Jeon, B.H., Kim, K.J., Ryu, P.D., Kwon, L.S., Kim, H.Y. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  5. Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Watanabe, M., Koike, H., Ishiba, T., Okada, T., Seo, S., Hirai, K. Bioorg. Med. Chem. (1997) [Pubmed]
  6. Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents. Krafte, D.S., Volberg, W.A. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  7. A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2). Huff, R., Collins, P., Kramer, S., Seibert, K., Koboldt, C., Gregory, S., Isakson, P. Inflamm. Res. (1995) [Pubmed]
  8. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Rosenstock, M., Danon, A., Rimon, G. Biochim. Biophys. Acta (1999) [Pubmed]
 
WikiGenes - Universities