Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

diazolidine pyrazolidine

Synonyms: Pyrazolidine, SureCN5595, AG-F-69730, CHEBI:33138, CTK1H3109, ...

Zelenin, K.N. et al., Cepelák, V. et al., Brogden, R.N., Cheon, H.G. et al., Rybák, M. et al.

Cheon, Kim, Kim, Rhee, Yang, Ahn, Park, Lee, Jung, Lee, Kim,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of pyrazolidine

Effect of carboxypeptidase N, aprotinin and anti-inflammatory drugs of pyrazolidine type on experimental inflammations in rats [1].
The anti-inflammatory effects of five pyrazolidine derivatives on white mice and laboratory rats were studied using models of thermal aseptic inflammation and inflammation induced by injection of carragenin and histamine, as well as models of "cotton-ball granuloma" and epinephrine (adrenaline)-induced pulmonary edema [2].

High impact information on pyrazolidine

The pyrazolidine derivatives, phenylbutazone and oxyphenbutazone, which are not generally used for analgesia since they differ from the pyrazolones in terms of efficacy and tolerance, are not discussed in this article [3].
In the present study, we identified novel DPP-IV inhibitors of pyrazolidine derivatives (Compounds 1 and 2) and characterized their biological effects in vitro and in vivo [4].
The ex vivo efficacy was markedly influenced by the height of the drug level in blood and by differences in the elimination kinetics of the pyrazolidine derivatives in human organism [5].
Pyrazolidine derivatives: a comparative study of their effects on platelet aggregation [5].

References

Effect of carboxypeptidase N, aprotinin and anti-inflammatory drugs of pyrazolidine type on experimental inflammations in rats. Rybák, M., Mansfeld, V., Grimová, J., Petáková, M. Pharmacology (1978) [Pubmed]
Anti-inflammatory activity of 2-acyl-5(3)-hydroxytetrahydro-1H-pyrazole derivatives. Zelenin, K.N., Bezhan, I.P., Pastushenkov, L.V., Gromova, E.G., Lesiovskaja, E.E., Chakchir, B.A., Melnikova, L.F. Arzneimittel-Forschung. (1999) [Pubmed]
Pyrazolone derivatives. Brogden, R.N. Drugs (1986) [Pubmed]
Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold. Cheon, H.G., Kim, S.S., Kim, K.R., Rhee, S.D., Yang, S.D., Ahn, J.H., Park, S.D., Lee, J.M., Jung, W.H., Lee, H.S., Kim, H.Y. Biochem. Pharmacol. (2005) [Pubmed]
Pyrazolidine derivatives: a comparative study of their effects on platelet aggregation. Cepelák, V., Cepeláková, H., Brůnová, B., Kuchar, M., Roubal, Z. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1979) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share