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MeSH Review

Pulmonary Edema

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Disease relevance of Pulmonary Edema


Psychiatry related information on Pulmonary Edema

  • Thus, the rapid administration of morphine produces pulmonary venoconstriction via histamine release from the lung, and the latter may account for the well-documented association between acute pulmonary edema and narcotic abuse [6].

High impact information on Pulmonary Edema


Chemical compound and disease context of Pulmonary Edema


Biological context of Pulmonary Edema


Anatomical context of Pulmonary Edema


Gene context of Pulmonary Edema

  • Lung injury parameters ((125)I-albumin leak, accumulation of myeloperoxidase, and wet lung weights) were measured and found to be consistently reduced in both lpr and gld mice [25].
  • Further, CFTR played a major role in fluid clearance in a mouse model of acute volume-overload pulmonary edema [26].
  • The accumulation of pulmonary edema fluid was not inhibited in TNFR-deficient compared with WT mice [27].
  • IFN-alpha alone did not cause extravasation of radiolabel or increase in wet lung weights, though when given in combination with IL-2, significantly greater extravasation (P less than 0.01) as well as increase in lung water weights (P less than 0.05) was observed compared to the response in mice treated with IL-2 alone [28].
  • This form of pulmonary edema has previously been postulated to be due to the in vivo induction of tumor necrosis factor-alpha (TNF-alpha) [29].

Analytical, diagnostic and therapeutic context of Pulmonary Edema


  1. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Göggel, R., Winoto-Morbach, S., Vielhaber, G., Imai, Y., Lindner, K., Brade, L., Brade, H., Ehlers, S., Slutsky, A.S., Schütze, S., Gulbins, E., Uhlig, S. Nat. Med. (2004) [Pubmed]
  2. Monensin and the prevention of tryptophan-induced acute bovine pulmonary edema and emphysema. Hammond, A.C., Carlson, J.R., Breeze, R.G. Science (1978) [Pubmed]
  3. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. Okusawa, S., Gelfand, J.A., Ikejima, T., Connolly, R.J., Dinarello, C.A. J. Clin. Invest. (1988) [Pubmed]
  4. Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. Turrens, J.F., Crapo, J.D., Freeman, B.A. J. Clin. Invest. (1984) [Pubmed]
  5. TGF-beta is a critical mediator of acute lung injury. Pittet, J.F., Griffiths, M.J., Geiser, T., Kaminski, N., Dalton, S.L., Huang, X., Brown, L.A., Gotwals, P.J., Koteliansky, V.E., Matthay, M.A., Sheppard, D. J. Clin. Invest. (2001) [Pubmed]
  6. Opiate action in the pulmonary circulation. Hakim, T.S., Grunstein, M.M., Michel, R.P. Pulmonary pharmacology. (1992) [Pubmed]
  7. Lung epithelial fluid transport and the resolution of pulmonary edema. Matthay, M.A., Folkesson, H.G., Clerici, C. Physiol. Rev. (2002) [Pubmed]
  8. Prevention of high-altitude pulmonary edema by nifedipine. Bärtsch, P., Maggiorini, M., Ritter, M., Noti, C., Vock, P., Oelz, O. N. Engl. J. Med. (1991) [Pubmed]
  9. Atrial natriuretic peptide and pulmonary edema. Spodick, D.H. N. Engl. J. Med. (1989) [Pubmed]
  10. Meprobamate poisoning and pulmonary edema. Axelson, J.A., Hagaman, J.F. N. Engl. J. Med. (1977) [Pubmed]
  11. Toxicology of hydrogen sulfide. Reiffenstein, R.J., Hulbert, W.C., Roth, S.H. Annu. Rev. Pharmacol. Toxicol. (1992) [Pubmed]
  12. Letter: Furosemide for high altitude pulmonary edema. Hultgren, H.N. JAMA (1975) [Pubmed]
  13. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., Shimizu, T. Nat. Immunol. (2000) [Pubmed]
  14. Terbutaline and maternal cardiac function. Wagner, J.M., Morton, M.J., Johnson, K.A., O'Grady, J.P., Speroff, L. JAMA (1981) [Pubmed]
  15. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Peters, C.J., Simpson, G.L., Levy, H. Annu. Rev. Med. (1999) [Pubmed]
  16. A fatal cytokine-induced systemic inflammatory response reveals a critical role for NK cells. Carson, W.E., Yu, H., Dierksheide, J., Pfeffer, K., Bouchard, P., Clark, R., Durbin, J., Baldwin, A.S., Peschon, J., Johnson, P.R., Ku, G., Baumann, H., Caligiuri, M.A. J. Immunol. (1999) [Pubmed]
  17. Hemodynamics of LeVeen shunt pulmonary edema. Darsee, J.R., Fulenwider, J.T., Rikkers, L.F., Ansley, J.D., Nordlinger, B.F., Ivey, G., Heymsfield, S.B. Ann. Surg. (1981) [Pubmed]
  18. Desensitization of the pulmonary adenylyl cyclase system: a cause of airway hyperresponsiveness in congestive heart failure? Borst, M.M., Beuthien, W., Schwencke, C., LaRosée, P., Marquetant, R., Haass, M., Kübler, W., Strasser, R.H. J. Am. Coll. Cardiol. (1999) [Pubmed]
  19. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Kaner, R.J., Ladetto, J.V., Singh, R., Fukuda, N., Matthay, M.A., Crystal, R.G. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  20. Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms. Lo, S.K., Everitt, J., Gu, J., Malik, A.B. J. Clin. Invest. (1992) [Pubmed]
  21. The relationship between right duct lymph flow and extravascular lung water in dogs given alpha-naphthylthiourea. Pine, M.B., Beach, P.M., Cottrell, T.S., Scola, M., Turino, G.M. J. Clin. Invest. (1976) [Pubmed]
  22. S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Gon, Y., Wood, M.R., Kiosses, W.B., Jo, E., Sanna, M.G., Chun, J., Rosen, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  23. Binding of charged ferritin to alveolar wall components and charge selectivity of macromolecular transport in permeability pulmonary edema in rats. Brody, J.S., Vaccaro, C.A., Hill, N.S., Rounds, S. Circ. Res. (1984) [Pubmed]
  24. Pilot study of low-dose interleukin-11 in patients with bone marrow failure. Kurzrock, R., Cortes, J., Thomas, D.A., Jeha, S., Pilat, S., Talpaz, M. J. Clin. Oncol. (2001) [Pubmed]
  25. Relationship of acute lung inflammatory injury to Fas/FasL system. Neff, T.A., Guo, R.F., Neff, S.B., Sarma, J.V., Speyer, C.L., Gao, H., Bernacki, K.D., Huber-Lang, M., McGuire, S., Hoesel, L.M., Riedemann, N.C., Beck-Schimmer, B., Zetoune, F.S., Ward, P.A. Am. J. Pathol. (2005) [Pubmed]
  26. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. Fang, X., Fukuda, N., Barbry, P., Sartori, C., Verkman, A.S., Matthay, M.A. J. Gen. Physiol. (2002) [Pubmed]
  27. Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumonia. Mizgerd, J.P., Peschon, J.J., Doerschuk, C.M. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  28. Combined effects of interferon alpha and interleukin 2 on the induction of a vascular leak syndrome in mice. Puri, R.K., Rosenberg, S.A. Cancer Immunol. Immunother. (1989) [Pubmed]
  29. Tumor necrosis factor-alpha plays a central role in interleukin-2-induced pulmonary vascular leak and lymphocyte accumulation. Dubinett, S.M., Huang, M., Lichtenstein, A., McBride, W.H., Wang, J., Markovitz, G., Kelley, D., Grody, W.W., Mintz, L.E., Dhanani, S. Cell. Immunol. (1994) [Pubmed]
  30. Treatment of acute low pressure pulmonary edema in dogs: relative effects of hydrostatic and oncotic pressure, nitroprusside, and positive end-expiratory pressure. Prewitt, R.M., McCarthy, J., Wood, L.D. J. Clin. Invest. (1981) [Pubmed]
  31. Ethchlorvynol (Placidyl)-induced pulmonary edema. Glauser, F.L., Smith, W.R., Caldwell, A., Hoshiko, M., Dolan, G.S., Baer, H., Olsher, N. Ann. Intern. Med. (1976) [Pubmed]
  32. Nitric oxide as a mediator of oxidant lung injury due to paraquat. Berisha, H.I., Pakbaz, H., Absood, A., Said, S.I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  33. Role of complement in endotoxin/platelet-activating factor-induced lung injury. Rabinovici, R., Yeh, C.G., Hillegass, L.M., Griswold, D.E., DiMartino, M.J., Vernick, J., Fong, K.L., Feuerstein, G. J. Immunol. (1992) [Pubmed]
  34. Asbestos fibers and pleural plaques in a general autopsy population. Churg, A. Am. J. Pathol. (1982) [Pubmed]
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