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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Inflammation


High impact information on Inflammation

  • These results show that the production of plasminogen activatory by PMNs is controlled by agents that affect inflammations, and that this control is not shared by other lytic enzymes known to be associated with these cells [6].
  • The relatively abundant expression of MIF in lens may have clinical significance, with the possibility of involvement in ocular inflammations that may follow damage to the lens [7].
  • The only significant difference between Dfy(-/-) and Dfy(+/+) mice that we found was in neutrophil migration in peritoneal inflammations induced by lipopolysaccharide and thioglycolate [8].
  • Medications targeting the somatostatin type 2 receptor (SSTR2) have been employed for pancreatic inflammations and cancers, possibly via the regulation of the transcription factor nuclear factor kappaB (NFkappaB) [9].
  • Overall, these results suggest that IFN-alpha is a relevant in vivo regulator of CD73 in the endothelial-leukocyte microenvironment in infections/inflammations, and thus has a fundamental role in controlling the extent of inflammation via CD73-dependent adenosine production [10].

Chemical compound and disease context of Inflammation


Biological context of Inflammation


Anatomical context of Inflammation


Gene context of Inflammation

  • A specific depletion of CCR5(+) cells could therefore be a useful strategy to reduce the cellular infiltrate in chronic inflammations [21].
  • CONCLUSION: These results suggest that a co-stimulus like LPS is necessary for IL-4 to make a strong induction of eotaxin in eosinophilic inflammations such as nasal polyposis [22].
  • Because chemokines are of vital importance in directing inflammatory leukocytes to the sites of inflammations, we have investigated the expression and function of CC-chemokine receptor (CCR) on human MCs [23].
  • Recently, HO-1 has been found to be upregulated after allergic inflammations of the lower airway [24].
  • In cutaneous inflammations, a large amount of nitric oxide (NO) is produced through induction of inducible nitric oxide synthase (iNOS) under the influence of proinflammatory cytokines, resulting in tissue damages in skin, as clarified in other organs [25].

Analytical, diagnostic and therapeutic context of Inflammation


  1. Antioxidative role of ocular melanin pigment in the model of lens induced uveitis. Bilgihan, A., Bilgihan, M.K., Akata, R.F., Aricioğlu, A., Hasanreisoğlu, B. Free Radic. Biol. Med. (1995) [Pubmed]
  2. Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation. Finsnes, F., Christensen, G., Lyberg, T., Sejersted, O.M., Skjønsberg, O.H. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  3. Protein farnesyltransferase inhibitors. Ayral-Kaloustian, S., Salaski, E.J. Current medicinal chemistry. (2002) [Pubmed]
  4. Tear histamine levels in vernal conjunctivitis and other ocular inflammations. Abelson, M.B., Baird, R.S., Allansmith, M.R. Ophthalmology (1980) [Pubmed]
  5. Substance P stimulates IL-1 production by astrocytes via intracellular calcium. Martin, F.C., Charles, A.C., Sanderson, M.J., Merrill, J.E. Brain Res. (1992) [Pubmed]
  6. Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors. Granelli-Piperno, A., Vassalli, J.D., Reich, E. J. Exp. Med. (1977) [Pubmed]
  7. A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens. Wistow, G.J., Shaughnessy, M.P., Lee, D.C., Hodin, J., Zelenka, P.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Luo, H., Chaudhuri, A., Zbrzezna, V., He, Y., Pogo, A.O. Mol. Cell. Biol. (2000) [Pubmed]
  9. Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src. Liu, A.M., Wong, Y.H. J. Biol. Chem. (2005) [Pubmed]
  10. IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulation. Niemelä, J., Henttinen, T., Yegutkin, G.G., Airas, L., Kujari, A.M., Rajala, P., Jalkanen, S. J. Immunol. (2004) [Pubmed]
  11. Clinical evaluation of a scintigraphic method for diagnosing inflammations/infections using indium-111-labeled nonspecific human IgG. Serafini, A.N., Garty, I., Vargas-Cuba, R., Friedman, A., Rauh, D.A., Neptune, M., Landress, L., Sfakianakis, G.N. J. Nucl. Med. (1991) [Pubmed]
  12. Fast diagnosis of abdominal infections and inflammations with technetium-99m-HMPAO labeled leukocytes. Lantto, E.H., Lantto, T.J., Vorne, M. J. Nucl. Med. (1991) [Pubmed]
  13. Neopterin concentrations in cerebrospinal fluid and serum as an aid in differentiating central nervous system and peripheral infections in children. Millner, M.M., Franthal, W., Thalhammer, G.H., Berghold, A., Aigner, R.M., Füger, G.F., Reibnegger, G. Clin. Chem. (1998) [Pubmed]
  14. In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen. Perianin, A., Roch-Arveiller, M., Giroud, J.P., Hakim, J. Biochem. Pharmacol. (1984) [Pubmed]
  15. Zinc and cadmium plasma and erythrocyte levels in prostatic carcinoma, BPH, urological malignancies, and inflammations. Feustel, A., Wennrich, R. Prostate (1986) [Pubmed]
  16. Effect of piroxicam on the chemotaxis and random migration of polymorphonuclear leucocytes after induction of immune and non immune inflammations. Pham-Huy, D., Roch-Arveiller, M., Lenoir, M., Muntaner, O., Giroud, J.P. Biomed. Pharmacother. (1985) [Pubmed]
  17. Comparative studies on lipid and colony-stimulating factor-induced macrophage growth. Yui, S., Yamazaki, M. J. Immunol. (1990) [Pubmed]
  18. In activated mast cells, IL-1 up-regulates the production of several Th2-related cytokines including IL-9. Hültner, L., Kölsch, S., Stassen, M., Kaspers, U., Kremer, J.P., Mailhammer, R., Moeller, J., Broszeit, H., Schmitt, E. J. Immunol. (2000) [Pubmed]
  19. Fas (CD95) and bcl-2 expression in active skin lesions of Behçet's disease. Bariş, Y.S., Yildiz, L., Sentürk, N., Kandemir, B. Journal of the European Academy of Dermatology and Venereology : JEADV. (2005) [Pubmed]
  20. Thrombomodulin levels in the plasma and joint fluid from patients with rheumatoid arthritis. Ichikawa, Y., Takaya, M., Shimizu, H., Moriuchi, J., Uchiyama, M., Morita, K., Hoshina, Y., Horiki, T. Tokai J. Exp. Clin. Med. (1993) [Pubmed]
  21. Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: a new strategy in the treatment of chronic inflammatory diseases and HIV. Brühl, H., Cihak, J., Stangassinger, M., Schlöndorff, D., Mack, M. J. Immunol. (2001) [Pubmed]
  22. Induction of eotaxin production by interleukin-4, interleukin-13 and lipopolysaccharide by nasal fibroblasts. Nonaka, M., Pawankar, R., Fukumoto, A., Ogihara, N., Sakanushi, A., Yagi, T. Clin. Exp. Allergy (2004) [Pubmed]
  23. Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4. Juremalm, M., Olsson, N., Nilsson, G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  24. Heme oxygenase (HO)-1 is upregulated in the nasal mucosa with allergic rhinitis. Elhini, A., Abdelwahab, S., Ikeda, K. Laryngoscope (2006) [Pubmed]
  25. Suppressive effect of zinc ion on iNOS expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocytes. Yamaoka, J., Kume, T., Akaike, A., Miyachi, Y. J. Dermatol. Sci. (2000) [Pubmed]
  26. Protection against infections by oral lactoferrin: evaluation in animal models. Teraguchi, S., Wakabayashi, H., Kuwata, H., Yamauchi, K., Tamura, Y. Biometals (2004) [Pubmed]
  27. Effects of radiosynovectomy with p-32 colloid therapy in hemophilia and rheumatoid arthritis. Soroa, V.E., del Huerto Velázquez Espeche, M., Giannone, C., Caviglia, H., Galatros, G., Fernández, D., Méndez, M., Naswetter, G.G., Nicolini, J.O. Cancer Biother. Radiopharm. (2005) [Pubmed]
  28. Floctafenine, a new non-narcotic analgesic. Peterfalvi, M., Deraedt, R., Benzoni, J., Chifflot, L., Fournex, R. Archives internationales de pharmacodynamie et de thérapie. (1975) [Pubmed]
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