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Chemical Compound Review:

DIPA N-propan-2-ylpropan-2-amine

Synonyms: AGN-PC-008TJJ, HSDB 931, NSC-6758, ACMC-1C066, CCRIS 6235, ...

Ota, T. et al., Gagnaire, F. et al., Kitamura, N. et al., Hegedüs, M. et al., Vo, E.

Ota, Itoh, Tachi, Kudoh, Watanabe, Yamamoto, Tadokoro, Maekawa, Kitamura, Ota, Mimura,

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Disease relevance of DIISOPROPYLAMINE

Among the eight amines tested for both upper airway irritation and pulmonary toxicity, diisopropylamine and di-n-butylamine showed a RD50TC/RD50 ratio of less than 1, indicating that the respiratory toxicity induced by these two amines would be related primarily to pulmonary effects [1].

High impact information on DIISOPROPYLAMINE

Morphiceptin was obtained at 40% yield under the optimal reaction conditions: substrate, 4 mM Tyr-Pro-OEt.HCl and 20 mM Phe-Pro-NH(2).HCl; enzyme, DP IV, 0.275 nkat; solvent, 60% ethylene glycol containing 20 mM phosphate buffer at pH 7.0; amine, 4.2 mM diisopropylamine at 4 degrees C for 24 h [2].
Furthermore, in order to analyze the effect of DADA on keratinocytes, we examined the effects of each component of this substance, diisopropylamine (DIA) and dichloroacetate (DCA), on keratinocytes [3].
Quantification was performed for butylamine, diisopropylamine, and triethylamine by gas chromatography following solvent desorption [4].
According to the structure-activity relationships cyclohexanes containing diisopropylamine in the basic group were the most effective derivatives [5].

References

Nasal irritation and pulmonary toxicity of aliphatic amines in mice. Gagnaire, F., Azim, S., Bonnet, P., Simon, P., Guenier, J.P., de Ceaurriz, J. Journal of applied toxicology : JAT. (1989) [Pubmed]
Synthesis of morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) by dipeptidyl aminopeptidase IV derived from Aspergillus oryzae. Ota, T., Itoh, A., Tachi, H., Kudoh, K., Watanabe, T., Yamamoto, Y., Tadokoro, T., Maekawa, A. J. Agric. Food Chem. (2005) [Pubmed]
Effects of diisopropylamine dichloroacetate on proliferation and differentiation of normal human keratinocytes in vitro. Kitamura, N., Ota, Y., Mimura, K. Skin Pharmacol. Appl. Skin Physiol. (1999) [Pubmed]
Application of colorimetric indicators and thermo-hand method to determine base permeation through chemical protective gloves. Vo, E. Journal of occupational and environmental hygiene. (2004) [Pubmed]
Antiarrhythmic activity of oximethers. Hegedüs, M., Petöcz, L., Budai, Z., Mezei, T. Acta physiologica Hungarica. (1995) [Pubmed]

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