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Chemical Compound Review

Triethylamin     N,N-diethylethanamine

Synonyms: Trietilamina, TRIETHYLAMINE, Triaethylamin, triethyl-amine, NEt3, ...
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Disease relevance of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H


Psychiatry related information on 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H

  • This PEGylation process was optimized at the following conditions: 0.2-0.3% (v/v) triethylamine concentration, 5.0-6.0-fold molar amount of PEG, reaction temperature of 25-45 degrees C, and reaction time of 30 min [6].
  • Intra-VTA microinjection of the selective PKA activator Sp-adenosine-3',5'-cyclic monophosphothioate triethylamine (Sp-cAMPS; 25-100 nmol/side) dose-dependently stimulated acute locomotion and exerted synergistic effects on locomotor activity when coinfused into the VTA with AMPH but had no detectable effect on acute i.p. AMPH-induced locomotion [7].

High impact information on 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H

  • Purified fractions of Ub1-alpha, Ub2-alpha, Ub3,4-alpha, and Ub > 10-alpha conjugates were isolated by preparative SDS-PAGE, dialyzed and treated with triethylamine to remove SDS, and dissolved in 10 mM HCOO-(Na+),pH 4 [8].
  • To establish the precise location of each esterified fatty acyl residue, we subjected Y to a very mild alkaline hydrolysis in the presence of triethylamine [9].
  • The triethylamine-treated derivative (lipid Y) has a molecular weight of 723 [9].
  • The first phosphorylation step (leading to phosphodiester intermediates) is carried out by treatment with o-chlorophenyl phosphorodi-(1,2,4-triazolide) followed by treatment with water and triethylamine [10].
  • Giant vacuole formation, of confirmed trans-Golgi origin (labeled with C5-ceramide, p230, golgin-97), is a cellular response to all tested amines in the series (> or = 2.5 mM), including triethylamine [11].

Biological context of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H


Anatomical context of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H


Associations of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H with other chemical compounds


Gene context of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H

  • Coincubation with Rp-cAMPS triethylamine canceled the suppression of DNA synthesis and MAPK activity by Fsk [27].
  • Studies using forskolin, 8-bromoadenosine 3', 5' cyclic monophosphate, dibutyryl cAMP, cholera toxin, and Rp-adenosine 3', 5'-cyclic monophosphothioate triethylamine, which measured changes in tension suggest that cAMP may be involved in mediating the actions of CGRP [28].
  • First, the optimization of CEC separation parameters are performed including the ACN concentration, triethylamine (TEA) content, buffer pH and ammonium acetate concentration [29].
  • This effect of corticotrophin-releasing factor was blocked by pretreatment with the cyclase-adenosine-3,5-monophosphate (cAMP) inhibitor Rp-adenosine-3,5-cyclic monophosphothiolate triethylamine (Rp-cAMPS) and partially blocked by the N-methyl-D-aspartate receptor antagonist MK-801 [30].
  • Using bovine submaxillary mucin as a model for release of O-glycans in the reducing state, and based on yields of neoglycolipids and side-products from "peeling" reactions and degradation, aqueous ethylamine 70% w/v at 22 degrees C for 48 h has been selected in preference to other conditions, triethylamine, sodium hydroxide, and hydrazine [31].

Analytical, diagnostic and therapeutic context of 1/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H


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  15. An outstanding catalyst for asymmetric transfer hydrogenation in aqueous solution and formic acid/triethylamine. Matharu, D.S., Morris, D.J., Clarkson, G.J., Wills, M. Chem. Commun. (Camb.) (2006) [Pubmed]
  16. Palladium-catalyzed tandem dimerization and cyclization of acetylenic ketones: a convenient method for 3,3'-bifurans using PdCl2(PPh3)2. Jeevanandam, A., Narkunan, K., Ling, Y.C. J. Org. Chem. (2001) [Pubmed]
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  31. Nonreductive release of O-linked oligosaccharides from mucin glycoproteins for structure/function assignments as neoglycolipids: application in the detection of novel ligands for E-selectin. Chai, W., Feizi, T., Yuen, C.T., Lawson, A.M. Glycobiology (1997) [Pubmed]
  32. A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol. Fulton, D., Falck, J.R., McGiff, J.C., Carroll, M.A., Quilley, J. J. Lipid Res. (1998) [Pubmed]
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