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Chemical Compound Review:

Sym-m-xylenol 3,5-dimethylphenol

Synonyms: sym.-m-Xylenol, Xylenol 200, CCRIS 724, SureCN28714, AGN-PC-00PZBF, ...

Huang, W.E. et al., Hopper, D.J. et al., Hopper, D.J. et al., Viggor, S. et al., Keat, M.J. et al.

Viggor, Heinaru, Loponen, Merimaa, Tenno, Heinaru,

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Disease relevance of NSC 9268

P-cresol and 3,5-xylenol methylhydroxylases in Pseudomonas putida N.C.I.B. 9896 [1].

High impact information on NSC 9268

Constitutive synthesis of enzymes responsible for methyl group oxidation in 3,5-xylenol degradation and an associated p-cresol methylhydroxylase in Pseudomonas putida NCIB 9869 was shown by their retention at high specific activities in cells transferred from 3,5-xylenol medium to glutamate medium [2].
A comparison of the oxidation rates of various compounds by whole cells of Pseudomonas putida 3, 5 indicated that m-cresol is metabolized by oxidation to 3-hydroxybenzoate followed by hydroxylation to gentisate, the ring-fission substrate, when grown with 3, 5-xylenol [3].
Gas chromatography-mass spectrometry (GC-MS) was performed to validate the FT-IR analysis, indicating that two carboxylic acids, 3-hydroxybenzoic acid and 2,5-dihydroxybenzoic acid, were present as m-cresol biotransformation products from 3,5-xylenol-grown cells, but were absent in m-cresol-grown cells [4].
The biodegradation of 3,4, 2,4, 2,3, 2,6 and 3,5-dimethylphenol in combination with phenol and p-cresol by axenic and mixed cultures of bacteria was investigated [5].

Biological context of NSC 9268

In this study, Pseudomonas putida NCIMB 9869 was grown with either 3,5-xylenol or m-cresol as the sole carbon source, each inducing different metabolic pathways for m-cresol biotransformation [4].

References

P-cresol and 3,5-xylenol methylhydroxylases in Pseudomonas putida N.C.I.B. 9896. Keat, M.J., Hopper, D.J. Biochem. J. (1978) [Pubmed]
Regulation of enzymes of the 3,5-xylenol-degradative pathway in Pseudomonas putida: evidence for a plasmid. Hopper, D.J., Kemp, P.D. J. Bacteriol. (1980) [Pubmed]
Pathways for the degradation of m-cresol and p-cresol by Pseudomonas putida. Hopper, D.J., Taylor, D.G. J. Bacteriol. (1975) [Pubmed]
Rapid characterization of microbial biodegradation pathways by FT-IR spectroscopy. Huang, W.E., Hopper, D., Goodacre, R., Beckmann, M., Singer, A., Draper, J. J. Microbiol. Methods (2006) [Pubmed]
Biodegradation of dimethylphenols by bacteria with different ring-cleavage pathways of phenolic compounds. Viggor, S., Heinaru, E., Loponen, J., Merimaa, M., Tenno, T., Heinaru, A. Environmental science and pollution research international. (2002) [Pubmed]

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