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Chemical Compound Review:

Butylthiol butane-1-thiol

Synonyms: Butanethiol, Mercaptobutane, butylmercaptan, n-Butanethiol, Mercaptan C4, ...

Ames, R.G. et al., Kirkpatrick, D.L. et al., Lea, M.A. et al., Abou-Donia, M.B. et al., Thomas, W.C. et al.

Lea, Randolph, Lee, desBordes,

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High impact information on n-Butanethiol

In the present work we observed increased acetylation of histones with allyl isothiocyanate and butanethiol but not with butyl sulfide or butyl disulfide [1].
Defoliants which have the potential to produce acute symptoms include DEF and Folex, both of which release odorous butyl mercaptan gas as a degradation product [2].
Uptake studies revealed that the disulfide is metabolized at the cell membrane with only one of the metabolites, n-butanethiol, being taken up into the cell [3].
Orally administered DEF was rapidly metabolized in the gastrointestinal tract to nBM, which apparently caused the late acute toxic effect [4].
Inhalation teratology studies of n-butyl mercaptan in rats and mice [5].

References

Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. Lea, M.A., Randolph, V.M., Lee, J.E., desBordes, C. Int. J. Cancer (2001) [Pubmed]
Mortality following cotton defoliation: San Joaquin Valley, California, 1970-1990. Ames, R.G., Gregson, J. J. Occup. Environ. Med. (1995) [Pubmed]
Effect of a hypoxic tumor cell cytotoxic disulfide on the membrane and DNA of tumor cells in culture. Kirkpatrick, D.L., King, K.M., Abu Sa'da, I., Kelln, R.A., Richardson, M.E., Siemann, D.W. Anticancer Drugs (1992) [Pubmed]
Delayed neurotoxic, late acute and cholinergic effects of S,S,S-tributyl phosphorotrithioate (DEF): subchronic (90 days) administration in hens. Abou-Donia, M.B., Graham, D.G., Abdo, K.M., Komeil, A.A. Toxicology (1979) [Pubmed]
Inhalation teratology studies of n-butyl mercaptan in rats and mice. Thomas, W.C., Seckar, J.A., Johnson, J.T., Ulrich, C.E., Klonne, D.R., Schardein, J.L., Kirwin, C.J. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1987) [Pubmed]

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