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Chemical Compound Review:

SQUALANE 2,6,10,15,19,23- hexamethyltetracosane

Synonyms: Cosbiol, Spinacane, Squalan, Robane, Vitabiosol, ...

Matyas, G.R. et al., Carroll, B.J. et al., Yarkoni, E. et al., Yoshino, S. et al.

Matyas, Wassef, Rao, Alving,

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High impact information on Hexamethyl tetracosane

Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil [1].
However, mAbs were also identified that reacted with SQE on PVDF membranes, but did not recognize either SQA or liposomal phospholipid [2].
To study a role for T cells in nonspecifically induced arthritis, rats were injected intraarticularly into ankle joints with mineral oils including 2,6,10,15,19,23-hexamethyltetracosane (squalene) and incomplete Freund's adjuvant [3].
The kinetics of solubilization of two non-polar oils (hexadecane and 2,6,10,15,19,23 hexamethyl tetracosane) by a pure non-ionic surfactant (n-dodecyl hexaethylene glycol ether) have been investigated using a recently developed technique [4].

Biological context of Hexamethyl tetracosane

The polyclonal antiserum produced by immunizing mice with [L(71% SQE+LA)] therefore contained a mixed population of antibody specificities and, as expected, the ELISA of polyclonal antiserum with PVDF membranes detected antibodies both to SQE and SQA [2].

References

Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil. Yarkoni, E., Rapp, H.J. Cancer Res. (1979) [Pubmed]
Induction and detection of antibodies to squalene. Matyas, G.R., Wassef, N.M., Rao, M., Alving, C.R. J. Immunol. Methods (2000) [Pubmed]
Recruitment of pathogenic T cells to synovial tissues of rats injected intraarticularly with nonspecific agents. Yoshino, S., Yoshino, J. Cell. Immunol. (1994) [Pubmed]
The kinetics of solubilization of single component non-polar oils by a non-ionic surfactant. Carroll, B.J., O'Rourke, B.G., Ward, A.J. J. Pharm. Pharmacol. (1982) [Pubmed]

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