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MeSH Review

Ankle Joint

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Disease relevance of Ankle Joint


Psychiatry related information on Ankle Joint

  • The wide distribution of group I disynaptic excitation in motoneurones innervating extensor, flexor and bifunctional muscles acting on hip, knee and ankle joints suggests that these pathways can play an important role in the reinforcement of ongoing locomotor activity throughout the limb [6].
  • Using a pressure algometer pain threshold (PT) measurements were carried out in the paraspinal area as well as at the knee and ankle joints in 30 adults with active rheumatoid arthritis (RA) and in 30 healthy adults [7].

High impact information on Ankle Joint

  • CONCLUSION: Scoring for assessment of RA disease activity would be more sensitive if separate joints such as the shoulder, elbow, knee, wrist, and ankle joints were weighted differently [8].
  • The inhibitory effect of kallistatin on the accumulation of inflammatory cells in ankle joints was accompanied by reduced TNFalpha and IL-1beta levels in joint homogenates [9].
  • RESULTS: OPN messenger RNA transcripts progressively increased in ankle joints during the course of K/BxN serum-transferred arthritis [10].
  • METHODS: Chondrocytes isolated by enzymatic digestion of cartilage obtained from subjects undergoing knee replacement for OA (n = 6) or from normal ankle joints of tissue donors (n = 7) were cultured in alginate beads in serum-free medium and treated for 21 days with 100 ng/ml IGF-1, 100 ng/ml OP-1, or both [11].
  • The ankle joints were injected on day 12 with an adenoviral construct encoding IKKbeta K-->M (dominant negative, IKKbeta-dn) or Ad.GFP [12].

Chemical compound and disease context of Ankle Joint


Biological context of Ankle Joint


Anatomical context of Ankle Joint


Associations of Ankle Joint with chemical compounds

  • Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor [23].
  • The localization of neurokinin A (NK-A) in the normal ankle joint of rats was investigated by an immunoelectron microscopic technique with specific antisera to NK-A [24].
  • Rats were injected with capsaicin (50 microl, 0.2%) into one ankle joint and mechanical withdrawal threshold measured before and after injection [25].
  • Injection of sodium urate crystals into one ankle joint in the rat produces arthritis which is fully developed within 24 h [26].
  • Ankle joint urate arthritis in rats is associated with increased responses to ankle stimulation and decreased responses to stimulation of the distal foot [21].

Gene context of Ankle Joint

  • Intra-articular expression of antagonists of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in arthritic rabbit knee and mouse ankle joints by direct adenoviral-mediated intraarticular delivery results in amelioration of disease pathology in both the treated and contralateral untreated joints [27].
  • OXP inhibited HgCl2-induced TNF-alpha mRNA transcription in spleen and ankle joints [28].
  • The number of VIP immunoreactive nerve fibres observed in ankle joints of arthritic and normal rats did not differ [29].
  • RIA showed that the concentration of NPY-like immunoreactivity (LI) was increased by 50% in the ankle joint [29].
  • The expression of IL-1beta was significantly decreased in the ankle joints of mice treated with IL-1Ra (P<0.01) [30].

Analytical, diagnostic and therapeutic context of Ankle Joint


  1. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K., Hanakawa, Y., Hashimoto, K., Nagata, K., Yoshimura, A. J. Clin. Invest. (2001) [Pubmed]
  2. Superantigen can reactivate bacterial cell wall-induced arthritis. Schwab, J.H., Brown, R.R., Anderle, S.K., Schlievert, P.M. J. Immunol. (1993) [Pubmed]
  3. Models of HTLV-I-induced diseases. Infectious transmission of HTLV-I in inbred rats and HTVL-I env-pX transgenic rats. Yoshiki, T., Ikeda, H., Tomaru, U., Ohya, O., Kasai, T., Yamashita, I., Morita, K., Yamazaki, H., Ishizu, A., Nakamaru, Y., Kikuchi, K., Tanaka, S., Wakisaka, A. Leukemia (1997) [Pubmed]
  4. Disruption of glial function enhances electroacupuncture analgesia in arthritic rats. Sun, S., Chen, W.L., Wang, P.F., Zhao, Z.Q., Zhang, Y.Q. Exp. Neurol. (2006) [Pubmed]
  5. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Ossowska, K., Konieczny, J., Wolfarth, S., Pilc, A. Neuropharmacology (2005) [Pubmed]
  6. Group I disynaptic excitation of cat hindlimb flexor and bifunctional motoneurones during fictive locomotion. Quevedo, J., Fedirchuk, B., Gosgnach, S., McCrea, D.A. J. Physiol. (Lond.) (2000) [Pubmed]
  7. Pain threshold in patients with rheumatoid arthritis and effect of manual oscillations. Dhondt, W., Willaeys, T., Verbruggen, L.A., Oostendorp, R.A., Duquet, W. Scand. J. Rheumatol. (1999) [Pubmed]
  8. Impact of shoulder, elbow, and knee joint involvement on assessment of rheumatoid arthritis using the American College of Rheumatology Core Data Set. Tanaka, E., Saito, A., Kamitsuji, S., Yamada, T., Nakajima, A., Taniguchi, A., Hara, M., Tomatsu, T., Yamanaka, H., Kamatani, N. Arthritis Rheum. (2005) [Pubmed]
  9. Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Wang, C.R., Chen, S.Y., Wu, C.L., Liu, M.F., Jin, Y.T., Chao, L., Chao, J. Arthritis Rheum. (2005) [Pubmed]
  10. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Jacobs, J.P., Pettit, A.R., Shinohara, M.L., Jansson, M., Cantor, H., Gravallese, E.M., Mathis, D., Benoist, C. Arthritis Rheum. (2004) [Pubmed]
  11. The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Loeser, R.F., Pacione, C.A., Chubinskaya, S. Arthritis Rheum. (2003) [Pubmed]
  12. Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. Tak, P.P., Gerlag, D.M., Aupperle, K.R., van de Geest, D.A., Overbeek, M., Bennett, B.L., Boyle, D.L., Manning, A.M., Firestein, G.S. Arthritis Rheum. (2001) [Pubmed]
  13. Functional MRI involving painful stimulation of the ankle and the effect of physiotherapy joint mobilization. Malisza, K.L., Gregorash, L., Turner, A., Foniok, T., Stroman, P.W., Allman, A.A., Summers, R., Wright, A. Magnetic resonance imaging. (2003) [Pubmed]
  14. Peripheral and central effect of baclofen on ankle joint stiffness in multiple sclerosis. Nielsen, J.F., Sinkjaer, T. Muscle Nerve (2000) [Pubmed]
  15. Reevaluation of some double-blind, randomized studies of dexibuprofen (Seractil): a state-of-the-art overview. Studies in patients with lumbar vertebral column syndrome, rheumatoid arthritis, distortion of the ankle joint, gonarthrosis, ankylosing spondylitis, and activated coxarthrosis. Rahlfs, V.W., Stat, C. Journal of clinical pharmacology. (1996) [Pubmed]
  16. Improved preservation of rat hindlimbs with the University of Wisconsin solution and butanedione monoxime. Norden, M.A., Rao, V.K., Southard, J.H. Plast. Reconstr. Surg. (1997) [Pubmed]
  17. Intra-articular corticosteroid reduces joint stiffness after an experimental periarticular fracture. Namba, R.S., Kabo, J.M., Dorey, F.J., Meals, R.A. The Journal of hand surgery. (1992) [Pubmed]
  18. Gait analysis in advanced Parkinson's disease--effect of levodopa and tolcapone. Shan, D.E., Lee, S.J., Chao, L.Y., Yeh, S.I. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (2001) [Pubmed]
  19. Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis. A combined immunohistochemical and radioimmunoassay analysis. Ahmed, M., Bjurholm, A., Schultzberg, M., Theodorsson, E., Kreicbergs, A. Arthritis Rheum. (1995) [Pubmed]
  20. Cellular adhesion molecules in rat adjuvant arthritis. Halloran, M.M., Szekanecz, Z., Barquin, N., Haines, G.K., Koch, A.E. Arthritis Rheum. (1996) [Pubmed]
  21. Effect of the forebrain on flexion reflexes in rats with ankle joint urate arthritis. Coderre, T.J., Wall, P.D. Pain (1988) [Pubmed]
  22. Adaptive control for backward quadrupedal walking. II. Hindlimb muscle synergies. Buford, J.A., Smith, J.L. J. Neurophysiol. (1990) [Pubmed]
  23. Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor. Biroc, S.L., Gay, S., Hummel, K., Magill, C., Palmer, J.T., Spencer, D.R., Sa, S., Klaus, J.L., Michel, B.A., Rasnick, D., Gay, R.E. Arthritis Rheum. (2001) [Pubmed]
  24. Neurokinin-A in bone and joint tissues: changes in adjuvant arthritis. Elhassan, A.M., Lindgren, J.U., Hultenby, K., Adem, A. J. Bone Miner. Res. (1999) [Pubmed]
  25. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord. Skyba, D.A., Radhakrishnan, R., Rohlwing, J.J., Wright, A., Sluka, K.A. Pain (2003) [Pubmed]
  26. Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant. Coderre, T.J., Wall, P.D. Pain (1987) [Pubmed]
  27. Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Kim, S.H., Lechman, E.R., Kim, S., Nash, J., Oligino, T.J., Robbins, P.D. Mol. Ther. (2002) [Pubmed]
  28. Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Kiely, P.D., Gillespie, K.M., Oliveira, D.B. Eur. J. Immunol. (1995) [Pubmed]
  29. Neuropeptide Y- and vasoactive intestinal polypeptide-like immunoreactivity in adjuvant arthritis: effects of capsaicin treatment. Ahmed, M., Bjurholm, A., Theodorsson, E., Schultzberg, M., Kreicbergs, A. Neuropeptides (1995) [Pubmed]
  30. Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist. Kim, J.M., Jeong, J.G., Ho, S.H., Hahn, W., Park, E.J., Kim, S., Yu, S.S., Lee, Y.W., Kim, S. Gene Ther. (2003) [Pubmed]
  31. Unmethylated oligo-DNA containing CpG motifs aggravates collagen-induced arthritis in mice. Miyata, M., Kobayashi, H., Sasajima, T., Sato, Y., Kasukawa, R. Arthritis Rheum. (2000) [Pubmed]
  32. Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers. Lichtman, S.N., Wang, J., Sartor, R.B., Zhang, C., Bender, D., Dalldorf, F.G., Schwab, J.H. Infect. Immun. (1995) [Pubmed]
  33. Ibuprofen in the treatment of acute ankle joint injuries. A double-blind study. Fredberg, U., Hansen, P.A., Skinhøj, A. The American journal of sports medicine. (1989) [Pubmed]
  34. Nitric oxide modulates articular sensory discharge and responsiveness to bradykinin in normal and arthritic rats in vivo. Kelly, D.C., Asghar, A.U., Marr, C.G., McQueen, D.S. Neuroreport (2001) [Pubmed]
  35. Effect of an ankle orthosis and ankle ligament anesthesia on ankle joint proprioception. Feuerbach, J.W., Grabiner, M.D., Koh, T.J., Weiker, G.G. The American journal of sports medicine. (1994) [Pubmed]
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