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Chemical Compound Review:

Sandopart 1-[[10-(2- aminocarbonylethyl)-7...

Synonyms: DEMOXYTOCIN, Demoxitocina, Demoxytocine, Demossitocina, Demoxytocinum, ...

Westergaard, J.G. et al., Pliska, V. et al., Chen, L. et al., Lange, A.P. et al.

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High impact information on DEMOXYTOCIN

Labour was induced or stimulated after random allocation of the mothers to one of three oxytocics (prostaglandin E2 orally, oxytocin intravenously, or demoxytocin buccally) [1].
Using as models the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated [2].
PGE2 tablets (Prostin) were given to 109 parturients and demoxytocin resoriblets (Sandopart) to 84 [3].
Use of oral oxytocics for stimulation of labor in cases of premature rupture of the membranes at term. A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets [3].
The efficacy of oral PGE2 tablets and buccal demoxytocin (resoriblets) for the induction of labor in cases of premature rupture of the membranes (PROM) after the 37th week of gestation has been evaluated in a prospective, randomized investigation of 193 women [3].

Biological context of DEMOXYTOCIN

Analogues of oxytocin and deaminooxytocin with 4-glutamine replaced by 4-glutamic acid methyl ester readily lose their uterotonic activity when incubated with rat serum, presumably by hydrolysis to the much less active 4-glutamic acid derivatives [4].

Anatomical context of DEMOXYTOCIN

On the other hand, inactivation of the deaminooxytocin analogue in the rat uterus, as demonstrated by the "oil-bath" technique, is only slightly more rapid than that of deaminooxytocin and distinctly slower than that of oxytocin [4].

References

Neonatal jaundice after labour induced or stimulated by prostaglandin E2 or oxytocin. Lange, A.P., Secher, N.J., Westergaard, J.G., Skovgård, I. Lancet (1982) [Pubmed]
Synthesis and pharmacology of novel analogues of oxytocin and deaminooxytocin: directed methods for the construction of disulfide and trisulfide bridges in peptides. Chen, L., Zoulíková, I., Slaninová, J., Barany, G. J. Med. Chem. (1997) [Pubmed]
Use of oral oxytocics for stimulation of labor in cases of premature rupture of the membranes at term. A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets. Westergaard, J.G., Lange, A.P., Pedersen, G.T., Secher, N.J. Acta obstetricia et gynecologica Scandinavica. (1983) [Pubmed]
Modes of inactivation of neurohypophysial hormones: significance of plasma disappearance rate for their physiological responses. Pliska, V., Rudinger, J. Clin. Endocrinol. (Oxf) (1976) [Pubmed]

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