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Chemical Compound Review:

Flagyl S 2-(2-methyl-5-nitro-imidazol- 1-yl)ethyl...

Synonyms: PubChem15676, Elyzol (TN), SureCN366213, Bio-0375, CHEBI:50688, ...

Ogunbanwo, J.A. et al., Bloch, B. et al., Sanyal, A.K., Roos, R.F., Homeida, M.A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Metronidazole benzoate

Metronidazole metabolism following oral benzoylmetronidazole suspension in children with giardiasis [1].
Metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets each given as a single 2 g bolus dose in an open controlled prospective study were found to be effective forms of treatment for Trichomonas vaginalis vaginitis [2].

High impact information on Metronidazole benzoate

A procedure is described for the rapid determination of benzoyl metronidazole in an oral suspension which is based on measurement of the change in absorbance at 276 nm during alkaline hydrolysis of the compound in 2 mol dm-3 NaOH [3].
Results from the in vitro studies indicated that halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine appeared to be effective trypanosomicidal agents against T. brucei brucei (Bassa strain), T. congolense (Zaria strain) and T. brucei gambiense (Abraka strain) [4].
A single 2-g dose of benzoylmetronidazole (Flagyl suspension) was given to patients with vaginal trichomoniasis in the second and third trimesters of pregnancy [5].

References

Metronidazole metabolism following oral benzoylmetronidazole suspension in children with giardiasis. Homeida, M.A., Daneshmend, T.K., Ali, H.M., Kaye, C.M. J. Antimicrob. Chemother. (1986) [Pubmed]
The treatment of Trichomonas vaginalis vaginitis. An open controlled prospective study comparing a single dose of metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets. Bloch, B., Smyth, E. S. Afr. Med. J. (1985) [Pubmed]
Rapid ultraviolet spectrophotometric assay of benzoyl metronidazole in an oral suspension. Sanyal, A.K. The Analyst. (1992) [Pubmed]
Effects of anti-protozoal drugs and histopathological studies on trypanosome species. Ogunbanwo, J.A., Agbonlahor, D.E., Adamu, A., Dalyop, P., Elesha, S.O., Fagbenro-Beyioku, A.F. FEMS Immunol. Med. Microbiol. (2001) [Pubmed]
Trichomoniasis treated with a single dose of benzoylmetronidazole. Roos, R.F. S. Afr. Med. J. (1978) [Pubmed]

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