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Chemical Compound Review

Tricolam     1-(2-ethylsulfonylethyl)-2- methyl-5-nitro...

Synonyms: Bioshik, Fasigin, Fasigyn, Fasygin, Simplotan, ...
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Disease relevance of tinidazole


Psychiatry related information on tinidazole

  • The efficacy of netilmicin combined with tinidazole (N + T) or clindamycin (N + C) in the treatment of severe abdominal infections was evaluated in a prospective randomized study with 20 patients in the N + T group and 21 patients in the N + C group [6].
  • The 4 regimens are relatively safe, as no abnormality in laboratory assessment was found, albeit the frequency of side effects (most of whom tinidazole related) and the difficulty of the schedules (6-10 tablets/day) may limit patient compliance [7].

High impact information on tinidazole

  • In a peri-urban shanty town in Lima, Peru, that was hyperendemic for Giardia lamblia, 44 children aged between 0.9 months and 10 years were effectively treated for Giardia lamblia with tinidazole [8].
  • To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken [9].
  • Preliminary results indicate that triple therapy with pantoprazole, clarithromycin and either metronidazole or tinidazole is effective in the treatment of Helicobacter pylori-associated disease; however, these findings require confirmation in large well-controlled studies [10].
  • Tinidazole was active against all anaerobes (MIC90, 2.0 micrograms/ml). beta-Lactamase was produced only by the B. fragilis isolate [11].
  • Eight hours after the last dose, the concentrations of tinidazole were 24.1 +/- 2.5 micrograms (mean +/- standard error of the mean)/g of prostatic tissue, 29.1 +/- 2.9 micrograms/g of vas deferens, 22.1 +/- 2.1 micrograms/g of epididymis, and 18.6 +/- 2.3 micrograms/g of testis [12].

Chemical compound and disease context of tinidazole


Biological context of tinidazole


Anatomical context of tinidazole


Associations of tinidazole with other chemical compounds


Gene context of tinidazole

  • The concentrations of tinidazole in serum and GCF were in a similar range (3.2-46.5 micrograms/mL) [23].
  • OBJECTIVE: To evaluate the efficacy of 1-week triple therapy with omeprazole, clarithromycin,and tinidazole (OCT) in Helicobacter pylori-positive older patients with dyspepsia [32].
  • When CBS was combined with amoxycillin or tinidazole, long-term disappearance of both CP bacteria and gastritis was achieved (p less than 0.0001) [33].
  • The procedure was used to quantitate tinidazole in patient sera [34].
  • Tinidazole had no effect on induction of EBV determined nuclear antigen (EBNA) or DNA synthesis, while immunoglobulin synthesis was increased in the presence of the drug [35].

Analytical, diagnostic and therapeutic context of tinidazole


  1. Treatment of giardiasis: comparative evaluation of ornidazole and tinidazole as a single oral dose. Jokipii, L., Jokipii, A.M. Gastroenterology (1982) [Pubmed]
  2. Amoxycillin plus tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. Oderda, G., Vaira, D., Holton, J., Ainley, C., Altare, F., Ansaldi, N. Lancet (1989) [Pubmed]
  3. Sensitivity of Gardnerella vaginalis to metabolites of metronidazole and tinidazole. Shanker, S., Munro, R. Lancet (1982) [Pubmed]
  4. Short and long term outcome of Helicobacter pylori positive resistant duodenal ulcers treated with colloidal bismuth subcitrate plus antibiotics or sucralfate alone. Bianchi Porro, G., Parente, F., Lazzaroni, M. Gut (1993) [Pubmed]
  5. Treatment of symptomatic intestinal amoebiasis with tinidazole. Garcia, E.G. Drugs (1978) [Pubmed]
  6. Comparative study of netilmicin/tinidazole versus netilmicin/clindamycin in the treatment of severe abdominal infections. Henning, C., Medén-Britth, G., Frölander, F., Karlsson, J., Dornbusch, K. Scand. J. Infect. Dis. (1984) [Pubmed]
  7. Helicobacter pylori infection: comparison among four different therapeutic regimens. Bologna, E., Stroppiana, M., Peyre, S., Rizzi, R., Sategna-Guidetti, C. Panminerva medica. (1992) [Pubmed]
  8. Rapid reinfection by Giardia lamblia after treatment in a hyperendemic Third World community. Gilman, R.H., Marquis, G.S., Miranda, E., Vestegui, M., Martinez, H. Lancet (1988) [Pubmed]
  9. A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study. Giercksky, K.E., Danielsen, S., Garberg, O., Grüner, O.P., Holter, O., Johnson, J.A., Nygaard, K., Ofstad, E., Stadaas, J., Viddal, K.O. Ann. Surg. (1982) [Pubmed]
  10. Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders. Fitton, A., Wiseman, L. Drugs (1996) [Pubmed]
  11. Susceptibilities of bovine summer mastitis bacteria to antimicrobial agents. Jousimies-Somer, H., Pyörälä, S., Kanervo, A. Antimicrob. Agents Chemother. (1996) [Pubmed]
  12. Concentrations of metronidazole and tinidazole in male genital tissues. Viitanen, J., Haataja, H., Männistö, P.T. Antimicrob. Agents Chemother. (1985) [Pubmed]
  13. Low-dose omeprazole plus clarithromycin and either tinidazole or amoxycillin for Helicobacter pylori infection. Tursi, A., Cammarota, G., Montalto, M., Papa, A., Veneto, G., Cuoco, L., Trua, F., Branca, G., Fedeli, G., Gasbarrini, G. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  14. A study of 4- and 7-day triple therapy with rabeprazole, high-dose levofloxacin and tinidazole rescue treatment for Helicobacter pylori eradication. Giannini, E.G., Bilardi, C., Dulbecco, P., Mamone, M., Santi, M.L., Testa, R., Mansi, C., Savarino, V. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  15. Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers. Spadaccini, A., De Fanis, C., Sciampa, G., Masciulli, V., Pantaleone, U., Di Virgilio, M., Magnarini, C., Pizzicannella, G. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  16. One-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus medium-dose clarithromycin and either tinidazole or amoxycillin. Cammarota, G., Cannizzaro, O., Tursi, A., Papa, A., Gasbarrini, A., Cuoco, L., Cianei, R., Armuzzi, A., Fedeli, P., Fedeli, G., Gasbarrini, G. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  17. Pantoprazole, azithromycin and tinidazole: short duration triple therapy for eradication of Helicobacter pylori infection. Calabrese, C., Di Febo, G., Areni, A., Scialpi, C., Biasco, G., Miglioli, M. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  18. Aspects of the pharmacology and pharmacokinetics of nitroimidazoles with special reference to tinidazole. Noguchi, Y., Tanaka, T. Drugs (1978) [Pubmed]
  19. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Mattila, J., Männistö, P.T., Mäntylä, R., Nykänen, S., Lamminsivu, U. Antimicrob. Agents Chemother. (1983) [Pubmed]
  20. On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole. Salo, J.P., Yli-Kauhaluoma, J., Salomies, H. Journal of pharmaceutical sciences. (2003) [Pubmed]
  21. Tinidazole: a nitroimidazole antiprotozoal agent. Fung, H.B., Doan, T.L. Clinical therapeutics. (2005) [Pubmed]
  22. Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion. Karhunen, M. British journal of clinical pharmacology. (1984) [Pubmed]
  23. Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis. Liew, V., Mack, G., Tseng, P., Cvejic, M., Hayden, M., Buchanan, N. J. Dent. Res. (1991) [Pubmed]
  24. Penetration of the blood brain barrier by metronidazole and tinidazole. Jokipii, A.M., Myllylä, V.V., Hokkanen, E., Jokipii, L. J. Antimicrob. Chemother. (1977) [Pubmed]
  25. Design and in vitro evaluation of oral colon targeted drug delivery systems for tinidazole. Krishnaiah, Y.S., Indira Muzib, Y., Srinivasa Rao, G., Bhaskar, P., Satyanarayana, V. Journal of drug targeting. (2002) [Pubmed]
  26. Tinidazole milk excretion and pharmacokinetics in lactating women. Evaldson, G.R., Lindgren, S., Nord, C.E., Rane, A.T. British journal of clinical pharmacology. (1985) [Pubmed]
  27. Concentrations of tinidazole in body fluids and tissues in gynaecological patients. Ripa, T., Weström, L., Mårdh, P.A., Andersson, K.E. Chemotherapy. (1977) [Pubmed]
  28. Tinidazole: a review of its antiprotozoal activity and therapeutic efficacy. Sawyer, P.R., Brogden, R.N., Pinder, R.M., Speight, T.M., Avery, G.S. Drugs (1976) [Pubmed]
  29. The cost-effectiveness of population Helicobacter pylori screening and treatment: a Markov model using economic data from a randomized controlled trial. Mason, J., Axon, A.T., Forman, D., Duffett, S., Drummond, M., Crocombe, W., Feltbower, R., Mason, S., Brown, J., Moayyedi, P. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  30. Antibiotic prophylaxis in hysterectomy--cefotaxime compared to ampicillin-tinidazole. McDonald, P.J., Sanders, T., Higgins, G., Finlay-Jones, L., Hakendorf, M., Turnidge, J., Jones, W. J. Antimicrob. Chemother. (1984) [Pubmed]
  31. Isolation of Mobiluncus species from clinical specimens by using cold enrichment and selective media. Smith, H.J., Moore, H.B. J. Clin. Microbiol. (1988) [Pubmed]
  32. The efficacy of omeprazole-based short-term triple therapy in Helicobacter pylori-positive older patients with dyspepsia. Moshkowitz, M., Brill, S., Konikoff, F.M., Reif, S., Arber, N., Halpern, Z. Journal of the American Geriatrics Society. (1999) [Pubmed]
  33. Antibacterial action of bismuth in relation to Campylobacter pyloridis colonization and gastritis. Marshall, B.J., Armstrong, J.A., Francis, G.J., Nokes, N.T., Wee, S.H. Digestion (1987) [Pubmed]
  34. Assay of tinidazole in human serum by high-performance thin-layer chromatography--comparison with high-performance liquid chromatography. Guermouche, M.H., Habel, D., Guermouche, S. Journal of AOAC International. (1999) [Pubmed]
  35. The effect of tinidazole on primary EBV infection and immunocompetence. Marklund, G., Ernberg, I., Britton, S., Lundberg, C. Scand. J. Infect. Dis. (1984) [Pubmed]
  36. Tinidazole in anaerobic infections: a review of its antibacterial activity, pharmacological properties and therapeutic efficacy. Carmine, A.A., Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.S. Drugs (1982) [Pubmed]
  37. Liquid chromatographic assay for metronidazole and tinidazole: pharmacokinetic and metabolic studies in human subjects. Nilsson-Ehle, I., Ursing, B., Nilsson-Ehle, P. Antimicrob. Agents Chemother. (1981) [Pubmed]
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