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Chemical Compound Review:

Mesotol ethyl 2-hydroxybenzoate

Synonyms: Salotan, Sal ether, Sal ethyl, SureCN39622, NSC-8209, ...

Jones, R.M. et al., Gadzinowski, M. et al.

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High impact information on Ethyl hydroxybenzoate

Studies of mutants with disruptions of genes of the beta-ketoadipate pathway with or without an additional salE mutation confirmed that ethyl salicylate and salicylate were channeled into the beta-ketoadipate pathway at the level of catechol and thence dissimilated by the cat gene products [1].
Mutations involving insertion of Km(r) cassettes into salA and salR eliminated expression of salicylate hydroxylase activity and the ability to grow on either salicylate or ethyl salicylate [1].
Its product, SalE, was shown to have esterase activity against short-chain alkyl esters of 4-nitrophenol but was also able to hydrolyze ethyl salicylate to ethanol and salicylic acid [1].

Analytical, diagnostic and therapeutic context of Ethyl hydroxybenzoate

Poly(epsilon-caprolactone) microspheres transferred into water were loaded with ethyl salicylate [2].

References

sal genes determining the catabolism of salicylate esters are part of a supraoperonic cluster of catabolic genes in Acinetobacter sp. strain ADP1. Jones, R.M., Pagmantidis, V., Williams, P.A. J. Bacteriol. (2000) [Pubmed]
Phase transfer and characterization of poly(epsilon-caprolactone) and poly(L-lactide) microspheres. Gadzinowski, M., Slomkowski, S., Elaïssari, A., Pichot, C. Journal of biomaterials science. Polymer edition. (2000) [Pubmed]

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