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Chemical Compound Review

SureCN119562     2-[(2,4-dichlorophenyl) carbamoyl]cycloprop...

Synonyms: LS-58646, AKOS005210179, FT-0665332, AC1L3AZ2, I14-14341, ...
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Disease relevance of Finish

  • Excess lung cancer risks furthermore were seen for Finish miners, for Finnish males in excavation work, and for Danish glassworkers [1].
  • To analyze the occurrence of root caries in relation to the periodontal state, we examined clinically a representative sample (n = 4,777) of Finish adults, aged 30 years and older [2].

Psychiatry related information on Finish


High impact information on Finish

  • These frequency data were valuable in determining the relationship of the CA alloantigen to the serologically defined TU GPIIIa polymorphism that is present in low frequency in the Finish population [4].
  • Model in hand, we examine the molecular events controlling "Start" (the commitment step to a new round of chromosome replication, bud formation, and mitosis) and "Finish" (the transition from metaphase to anaphase, when sister chromatids are pulled apart and the bud separates from the mother cell) in wild-type cells and 50 mutants [5].
  • In our model, the transition from G1 to S/M ('Start') is driven by cell growth, and the reverse transition ('Finish') is driven by completion of DNA synthesis and proper alignment of chromosomes on the metaphase plate [6].
  • We evaluated the DRD4 genotype in 226 Finish adult males, 113 of whom were alcoholics, many of the early onset type with features of impulsivity and antisocial traits [7].
  • First, we present a simple model of the antagonistic interactions between cyclin-dependent kinases and the anaphase promoting complex, which shows how progress through the cell cycle can be thought of as irreversible transitions (Start and Finish) between two stable states (G1 and S-G2-M) of the regulatory system [8].

Biological context of Finish

  • Mitochondrial DNA sequences from 74 Swiss individuals were compared to sequences from British and Finish populations [9].

Anatomical context of Finish


Gene context of Finish

  • We propose that a protein-phosphatase, by up-regulating the APC and by stabilizing the CKI, plays an essential role at Finish [11].
  • Irreversible transitions between these two self-maintaining steady states drive progress through the cell cycle: at "Start" a cell leaves the G1 state and commences chromosome replication, and at "Finish" the cell separates the products of replication to the incipient daughter cells and re-enters G1 [11].


  1. Silica dust and lung cancer: results from the Nordic occupational mortality and cancer incidence registers. Lynge, E., Kurppa, K., Kristofersen, L., Malker, H., Sauli, H. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Association between root caries occurrence and periodontal state. Vehkalahti, M., Paunio, I. Caries Res. (1994) [Pubmed]
  3. The effect of clozapine on the course of illness in chronic schizophrenia: focus on treatment outcome in out-patients. Joffe, G., Venäläinen, E., Tupala, J., Hiltunen, O., Wahlbeck, K., Gädeke, R., Rimon, R. International clinical psychopharmacology. (1996) [Pubmed]
  4. Amino acid 489 is encoded by a mutational "hot spot" on the beta 3 integrin chain: the CA/TU human platelet alloantigen system. Wang, R., McFarland, J.G., Kekomaki, R., Newman, P.J. Blood (1993) [Pubmed]
  5. Kinetic analysis of a molecular model of the budding yeast cell cycle. Chen, K.C., Csikasz-Nagy, A., Gyorffy, B., Val, J., Novak, B., Tyson, J.J. Mol. Biol. Cell (2000) [Pubmed]
  6. Model scenarios for evolution of the eukaryotic cell cycle. Novak, B., Csikasz-Nagy, A., Gyorffy, B., Nasmyth, K., Tyson, J.J. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1998) [Pubmed]
  7. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Adamson, M.D., Kennedy, J., Petronis, A., Dean, M., Virkkunen, M., Linnoila, M., Goldman, D. Am. J. Med. Genet. (1995) [Pubmed]
  8. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. Tyson, J.J., Novak, B. J. Theor. Biol. (2001) [Pubmed]
  9. Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations. Pult, I., Sajantila, A., Simanainen, J., Georgiev, O., Schaffner, W., Pääbo, S. Biol. Chem. Hoppe-Seyler (1994) [Pubmed]
  10. Transfusion policies in coronary artery bypass--a nationwide survey in Finland. Kytölä, L., Nuutinen, L., Myllylä, G. Acta anaesthesiologica Scandinavica. (1998) [Pubmed]
  11. Finishing the cell cycle. Novák, B., Tóth, A., Csikász-Nagy, A., Györffy, B., Tyson, J.J., Nasmyth, K. J. Theor. Biol. (1999) [Pubmed]
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