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Chemical Compound Review

FIGLU     2-(aminomethylideneamino) pentanedioic acid

Synonyms: NSC-334078, AC1L1AAT, NSC334078, AR-1K7041, AC1Q5VO3, ...
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Disease relevance of NSC66354


Psychiatry related information on NSC66354


High impact information on NSC66354


Biological context of NSC66354

  • Two of the mutants exhibit an uninducible phenotype, whereas the third mutant appears to be defective in the structural gene for formiminoglutamate iminohydrolase [5].

Associations of NSC66354 with other chemical compounds


  1. A folate-dependent metabolite in amniotic fluid from pregnancies with normal or trisomy 21 chromosomes. Baggot, P.J., Eliseo, A.J., Kalamarides, J.A., Shoemaker, J.D. Fetal. Diagn. Ther. (2006) [Pubmed]
  2. The molecular basis of glutamate formiminotransferase deficiency. Hilton, J.F., Christensen, K.E., Watkins, D., Raby, B.A., Renaud, Y., de la Luna, S., Estivill, X., MacKenzie, R.E., Hudson, T.J., Rosenblatt, D.S. Hum. Mutat. (2003) [Pubmed]
  3. Urinary formiminoglutamate in man. Normal values related to sex and age. Effects of low calorie intake and alcohol consumption. Rosenauerová-Ostrá, A., Hilgertová, J., Sonka, J. Clin. Chim. Acta (1976) [Pubmed]
  4. Reaction of formiminoglutamate with liver glutamate dehydrogenase. Vińa, J., Hems, R., Krebs, H.A. Biochem. J. (1978) [Pubmed]
  5. Histidine dissimilation in Streptomyces coelicolor. Kendrick, K.E., Wheelis, M.L. J. Gen. Microbiol. (1982) [Pubmed]
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