Disease relevance of NSC66354

• RESULTS: FIGLU was significantly lower in pregnancies with Down syndrome [1].
• Features of a severe phenotype, first identified in patients of Japanese descent, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation [2].

Psychiatry related information on NSC66354

• Urinary formiminoglutamate in man. Normal values related to sex and age. Effects of low calorie intake and alcohol consumption [3].

High impact information on NSC66354

• 4. At pH 9.3, i.e. under the conditions for the assay of glutamate by glutamate dehydrogenase, formiminoglutamate reacts readily with the enzyme [4].
• Reaction of formiminoglutamate with liver glutamate dehydrogenase [4].
• The median FIGLU level was 1.3 in amniotic fluid from control fetuses [1].
• Gas liquid chromatography/mass spectrometry was used to quantitate FIGLU, which is elevated in folate deficiency [1].
• Decreased FIGLU might result from accelerated activity of one or more genes on chromosome 21, by a gene dosage effect [1].

Biological context of NSC66354

• Two of the mutants exhibit an uninducible phenotype, whereas the third mutant appears to be defective in the structural gene for formiminoglutamate iminohydrolase [5].

Associations of NSC66354 with other chemical compounds

• 2. The equilibrium constant at pH 7.0 was 0.017 micrometer with formiminoglutamate, i.e. about one two-hundredths that with glutamate [4].

References