The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

LS-154045     2-(1-amino-1-cyclohexyl- ethyl)-4,6-dibromo...

Synonyms: AC1L3M5P, C14H20Br2N2.HCl, Bromhexine hydrochloride [USAN:JAN]
This record was replaced with 91479.
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

 

High impact information on 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • The absorption of bromhexine from Bromhexin tablets 8 mg, DAK has been compared with that from Bisolvon tablets 8 mg, Boehringer Ingelheim, in a two-way complete crossover study [3].
  • The effect of an intravenous expectorant agent, i.e. Bisolvon, on the secretory activity of the tracheal mucosa of the dog was studied with the scanning electron microscope [4].
  • The rapid secretory response to the expectorant, Bisolvon, confirmed the active and important role of the tracheal mucociliary clearance mechanism for the protection of the lower respiratory tract [4].
 

Chemical compound and disease context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

 

Anatomical context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • A review of the literature together with the results of this trial suggest that, when adequate consideration is given to a number of therapeutic variables, Bisolvon will be effective medication for most patients with chronic bronchitis associated with thick, tenacious sputum [5].
 

Gene context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • It is concluded that Bromhexin, DAK and Bisolvon are bioequivalent [3].
 

Analytical, diagnostic and therapeutic context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • After the oral administration of Bisolvon Griblettes corresponding to 30 mg codeine phosphate to seven subjects maximum codeine concentrations were obtained after 1-2 h and codeine remained detectable generally 24 h post dosing [6].

References

  1. Double-blind crossover trial of bisolvon in the treatment of chronic bronchitis. Bristow, V. Med. J. Aust. (1976) [Pubmed]
  2. Bromhexine in the treatment of otitis media with effusion. Stewart, I.A., Guy, A.M., Allison, R.S., Thomson, N.J. Clinical otolaryngology and allied sciences. (1985) [Pubmed]
  3. Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans. Bechgaard, E., Nielsen, A. Biopharmaceutics & drug disposition. (1982) [Pubmed]
  4. The effect of an expectorant on the tracheal mucosa. A scanning-electron microscopic study. Harada, Y., Sasaki, H., Gaafar, H. ORL J. Otorhinolaryngol. Relat. Spec. (1977) [Pubmed]
  5. Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis. Armstrong, M.L. Med. J. Aust. (1976) [Pubmed]
  6. Influence of hydrolysis procedures on the urinary concentrations of codeine and morphine in relation to doping analysis. Delbeke, F.T., Debackere, M. Journal of pharmaceutical and biomedical analysis. (1993) [Pubmed]
 
WikiGenes - Universities