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Chemical Compound Review

LS-154045     2-(1-amino-1-cyclohexyl- ethyl)-4,6-dibromo...

Synonyms: AC1L3M5P, C14H20Br2N2.HCl, Bromhexine hydrochloride [USAN:JAN]
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Disease relevance of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline


High impact information on 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • The absorption of bromhexine from Bromhexin tablets 8 mg, DAK has been compared with that from Bisolvon tablets 8 mg, Boehringer Ingelheim, in a two-way complete crossover study [3].
  • The effect of an intravenous expectorant agent, i.e. Bisolvon, on the secretory activity of the tracheal mucosa of the dog was studied with the scanning electron microscope [4].
  • The rapid secretory response to the expectorant, Bisolvon, confirmed the active and important role of the tracheal mucociliary clearance mechanism for the protection of the lower respiratory tract [4].

Chemical compound and disease context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline


Anatomical context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • A review of the literature together with the results of this trial suggest that, when adequate consideration is given to a number of therapeutic variables, Bisolvon will be effective medication for most patients with chronic bronchitis associated with thick, tenacious sputum [5].

Gene context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • It is concluded that Bromhexin, DAK and Bisolvon are bioequivalent [3].

Analytical, diagnostic and therapeutic context of 2-(1-amino-1-cyclohexyl-ethyl)-4,6-dibromo-aniline

  • After the oral administration of Bisolvon Griblettes corresponding to 30 mg codeine phosphate to seven subjects maximum codeine concentrations were obtained after 1-2 h and codeine remained detectable generally 24 h post dosing [6].


  1. Double-blind crossover trial of bisolvon in the treatment of chronic bronchitis. Bristow, V. Med. J. Aust. (1976) [Pubmed]
  2. Bromhexine in the treatment of otitis media with effusion. Stewart, I.A., Guy, A.M., Allison, R.S., Thomson, N.J. Clinical otolaryngology and allied sciences. (1985) [Pubmed]
  3. Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans. Bechgaard, E., Nielsen, A. Biopharmaceutics & drug disposition. (1982) [Pubmed]
  4. The effect of an expectorant on the tracheal mucosa. A scanning-electron microscopic study. Harada, Y., Sasaki, H., Gaafar, H. ORL J. Otorhinolaryngol. Relat. Spec. (1977) [Pubmed]
  5. Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis. Armstrong, M.L. Med. J. Aust. (1976) [Pubmed]
  6. Influence of hydrolysis procedures on the urinary concentrations of codeine and morphine in relation to doping analysis. Delbeke, F.T., Debackere, M. Journal of pharmaceutical and biomedical analysis. (1993) [Pubmed]
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