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Chemical Compound Review

Flegamin     2,4-dibromo-6-[(cyclohexyl- methyl...

Synonyms: Fluibron, Bromhexina, bromhexine, Bromhexinum, Fluibron (TN), ...
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Disease relevance of bromhexine


High impact information on bromhexine


Chemical compound and disease context of bromhexine


Biological context of bromhexine


Anatomical context of bromhexine

  • The method was applied to the determination of bromhexine in blood serum and a pharmaceutical preparation [16].
  • These findings suggest that the enzymes which are liberated from lysosomes into the cytoplasm by bromhexine may, at least in a part, be involved in the mucolytic action of the agent on AGP contained in mucus granules of the submucosal gland [17].
  • The effect, studied using 99mTc-labelled red blood cells as a marker, was of similar quantity to that brought about by administering 16, 25 and 40 mg kg-1 doses of bromhexine [18].
  • CONCLUSION: Bromhexine has shown interference in blastocyst attachment, conception, reduction in number of implantation sites and dwarfing of fetuses; hence, it is a potential candidate for antiimplantation [15].
  • The role of alveolar macrophages in surfactant turnover. An experimental study with metabolite VIII of bromhexine (Ambroxol) [19].

Associations of bromhexine with other chemical compounds


Gene context of bromhexine


Analytical, diagnostic and therapeutic context of bromhexine

  • Determination of bromhexine in plasma by reversed-phase liquid chromatography. Interference of lipoproteins on extraction [8].
  • Patients received, at random, over a period of 2 weeks, either 2 ml saline or 2 ml bromhexine (2 mg/ml) t.i.d. by means of a home nebulizer [1].
  • Albumin excretion was similar after treatment with bromhexine and placebo in all 3 groups [normoalbuminurics 3.6 (1.7-13.5) versus 3.3 (1.9-13.2) micrograms/min.; microalbuminurics 40 (20-128) versus 37 (20-103); macroalbuminurics 396 (247-2160) versus 443 (292-2592)] [25].
  • PURPOSE: Quantitative evaluation of properties of bromhexine (B) for expression of uterine proteins in ovariectomized (OVX) and pregnant rats [15].
  • Expectorant drugs ambroxol (AX) and bromhexine (BX) were determined by capillary isotachophoresis (ITP) with conductimetric detection [29].


  1. Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. Van Bever, H.P., Bosmans, J., Stevens, W.J. Allergy (1987) [Pubmed]
  2. Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis. Tsujimoto, T., Tsuruzono, T., Hoppo, K., Matsumura, Y., Yamao, J., Fukui, H. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  3. Bromhexine treatment of Sjögren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva. Manthorpe, R., Frost-Larsen, K., Høj, L., Isager, H., Prause, J.U. Scand. J. Rheumatol. (1981) [Pubmed]
  4. Influence of bromhexine on tear lysozome level in keratoconjunctivitis sicca. Scharf, J.M., Obedeanu, N., Meshulam, T., Nahir, M., Merzbach, D., Scharf, J.A., Zonis, S. Am. J. Ophthalmol. (1981) [Pubmed]
  5. Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis. Armstrong, M.L. Med. J. Aust. (1976) [Pubmed]
  6. In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. Ottonello, L., Arduino, N., Bertolotto, M., Dapino, P., Mancini, M., Dallegri, F. Br. J. Pharmacol. (2003) [Pubmed]
  7. Determination of sulfametoxazole, sulfadiazine and associated compounds in pharmaceutical preparations by capillary zone electrophoresis. Berzas Nevado, J.J., Castañeda Peñalvo, G., Guzmán Bernardo, F.J. Journal of chromatography. A. (2001) [Pubmed]
  8. Determination of bromhexine in plasma by reversed-phase liquid chromatography. Interference of lipoproteins on extraction. Johansson, M., Lenngren, S. J. Chromatogr. (1988) [Pubmed]
  9. Application of bromhexine metabolite VIII (NA 872) and bromhexine-glucose in treatment of adult respiratory distress syndrome; experimental and clinical results . Kuckelt, W., Dauberschmidt, R., Scharfenberg, J., Winsel, K., Lachmann, B., Frenzke, H., Hieronymi, U., Mrochen, H., Meyer, M. Respiration; international review of thoracic diseases. (1980) [Pubmed]
  10. Erythromycin and bromhexine in acute exacerbations of chronic bronchitis. A study on sputum penetration and clinical effectiveness. Maesen, F.P., Davies, B.I., Brouwers, J., Rubingh, G. European journal of respiratory diseases. (1982) [Pubmed]
  11. Assay of bromhexine in human plasma by capillary gas--liquid chromatography with nitrogen-selective detection and selected ion monitoring. Schmid, J., Koss, F.W. J. Chromatogr. (1982) [Pubmed]
  12. Percutaneous absorption of bromhexine in rats. Ogiso, T., Iwaki, M., Tsuji, S. Chem. Pharm. Bull. (1991) [Pubmed]
  13. Effects of tea catechin inhalation on methicillin-resistant Staphylococcus aureus in elderly patients in a hospital ward. Yamada, H., Ohashi, K., Atsumi, T., Okabe, H., Shimizu, T., Nishio, S., Li, X.D., Kosuge, K., Watanabe, H., Hara, Y. J. Hosp. Infect. (2003) [Pubmed]
  14. The role of vagal reflex in mechanism of secretagogic action of bromhexine. Takeda, H., Abe, Y., Misawa, M., Yanaura, S., Kuroiwa, Y. Jpn. J. Pharmacol. (1984) [Pubmed]
  15. Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat. Singh, N., Malaviya, B. Contraception. (2006) [Pubmed]
  16. Flow-injection extraction-spectrophotometric determination of bromhexine with orange IV. Pérez-Ruiz, T., Martínez-Lozano, C., Sanz, A., Mondéjar, S. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
  17. A role of lysosomal enzymes in the mechanism of mucolytic action of bromhexine. Takeda, H., Misawa, M., Yanaura, S. Jpn. J. Pharmacol. (1983) [Pubmed]
  18. Influence of chinoin-170, a novel antitussive, on the mucociliary activity in respiratory airways of rats, rabbits, guinea-pigs and man. Saano, V., Minker, E., Joki, S., Virta, P., Nuutinen, J., Korbonits, D. J. Pharm. Pharmacol. (1993) [Pubmed]
  19. The role of alveolar macrophages in surfactant turnover. An experimental study with metabolite VIII of bromhexine (Ambroxol). Eckert, H., Lux, M., Lachmann, B. Lung (1983) [Pubmed]
  20. Determination of bromhexine as its trifluoroacetyl derivative by gas-liquid chromatography with electron-capture detection. De Leenheer, A.P., Vandecasteele-Thienpont, L.M. J. Chromatogr. (1979) [Pubmed]
  21. Studies on the formation of cyclohexylamine and N-methylcyclohexylamine from bromhexine in animals and man, and simultaneous determination of cyclohexylamine and N-methylcyclohexylamine by gas chromatography. Matsumura, R., Kohei, H. J. Chromatogr. (1976) [Pubmed]
  22. The effects of bromhexine hydrochloride and S-carboxymethyl-L-cysteine on guinea-pig uterine microflora. Malhi, J.S., Gard, P.R., Hanlon, G.W., Marriott, C. J. Pharm. Pharmacol. (1987) [Pubmed]
  23. Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection. Bazylak, G., Nagels, L.J. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
  24. Effects of expectorants on the canine tracheal ciliated cells. Yanaura, S., Imamura, N., Misawa, M. Jpn. J. Pharmacol. (1981) [Pubmed]
  25. The effect of bromhexine on albumin excretion in insulin dependent diabetes. Marshall, S.M., Shearing, P.A., Shelley, J.H., Alberti, K.G. Diabète & métabolisme. (1991) [Pubmed]
  26. Effect of bromhexine on Sjögren's syndrome accompanied by rheumatoid arthritis. Kawashima, K. Nippon Ika Daigaku Zasshi (1988) [Pubmed]
  27. Bromhexine and COPD. Gupta, S.K., Misra, K. The Journal of the Association of Physicians of India. (1985) [Pubmed]
  28. Acute generalized exanthematous pustulosis associated with polysensitivity to paracetamol and bromhexine: the diagnostic role of in vitro interferon-gamma release test. Halevy, S., Cohen, A., Livni, E. Clin. Exp. Dermatol. (2000) [Pubmed]
  29. Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis. Pospísilová, M., Polásek, M., Jokl, V. Journal of pharmaceutical and biomedical analysis. (2001) [Pubmed]
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