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Chemical Compound Review:

PubChem1478 2-amino-5-chloro-phenol

Synonyms: SureCN103329, CPD-9158, AG-C-31634, ACMC-209h2j, ACN-S003807, ...

Valentovic, M. et al., Yoshida, T. et al., Xiao, Y. et al.

Valentovic, Meadows, Harmon, Ball, Hong, Rankin,

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Disease relevance of EINECS 249-020-3

These results suggest that 2-amino-5-chlorophenol toxicity was not mediated through an iron-dependent mechanism [1].
These two genes were actively expressed in Escherichia coli, and recombinant E. coli cells catalyzed the conversion of 4CNB to 2-amino-5-chlorophenol, which is the ring-cleavage substrate in the degradation of 4CNB [2].

High impact information on EINECS 249-020-3

This study examined the in vitro toxicity of 2-amino-5-chlorophenol in renal cortical slices from Fischer 344 rats and specifically assessed induction of lipid peroxidation and depletion of renal glutathione [1].
Lipid peroxidation was induced within 60 min by 1 mM 2-amino-5-chlorophenol in renal slices relative to control tissue [1].
Pyruvate-directed gluconeogenesis was diminished in a concentration-dependent manner following a 90-min incubation with 0, 0.25, 0.5, and 1 mM 2-amino-5-chlorophenol [1].
The time course for excretion of five metabolites--2-chloro-5-nitrophenol,N-acetyl-S-(4-nitrophenyl)- L-cysteine, 2,4-dichloroaniline, p-chloroaniline, and 2-amino-5-chlorophenol-were determined by reversed-phase HPLC analysis of urine collected from six subjects during their hospitalization after accidental exposure to p-CNB [3].

References

2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: effect of antioxidants and sulfhydryl agents. Valentovic, M., Meadows, M.K., Harmon, R.C., Ball, J.G., Hong, S.K., Rankin, G.O. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
Characterization of genes involved in the initial reactions of 4-chloronitrobenzene degradation in Pseudomonas putida ZWL73. Xiao, Y., Wu, J.F., Liu, H., Wang, S.J., Liu, S.J., Zhou, N.Y. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
Pharmacokinetic study of p-chloronitrobenzene in humans suffering from acute poisoning. Yoshida, T., Tabuchi, T., Andoh, K. Drug Metab. Dispos. (1993) [Pubmed]

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