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Chemical Compound Review

Androstanol     (3S,5S,8S,9S,10S,13S,14S)- 10,13-dimethyl-2...

Synonyms: Androstan-3-ol, CHEMBL198053, AG-D-48841, SureCN8495050, HMDB05830, ...
 
 
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High impact information on Androstanol

  • Each of these were characterized by co-transfection experiments, directed mutagenesis, gel shift assays, and response to specific antagonists RU486 and androstanol [1].
  • In contrast, the CAR deactivator androstanol activates both mouse and human PXR [2].
  • Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo [3].
  • We found that the pure VDR antagonist ZK168281 and the human CAR inverse agonist clotrimazole are both effective inhibitors of the CoA interaction of their respective receptors, whereas ZK168281 resembled more the mouse CAR inverse agonist androstanol in its ability to recruit CoR proteins [4].
  • In the transactivation analysis of Baikal seal CAR, neither repression by androstanol and androstenol, nor activation by estrone and estradiol, which are recognized as endogenous ligands for mouse and human CARs, was detected [5].
 

Associations of Androstanol with other chemical compounds

  • We have used ESR and NMR linewidth broadening by spin-labels to determine the overall orientation of spin-labeled analogues of cholesterol and androstanol in egg lecithin bilayers [6].
 

Gene context of Androstanol

  • Four different positional isomers of spin labeled fatty acids and spin labeled androstanol experienced more restricted motion in porcine HDL than in the human HDL2 and HDL3 subclasses [7].

References

  1. Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. Gerbal-Chaloin, S., Daujat, M., Pascussi, J.M., Pichard-Garcia, L., Vilarem, M.J., Maurel, P. J. Biol. Chem. (2002) [Pubmed]
  2. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Moore, L.B., Parks, D.J., Jones, S.A., Bledsoe, R.K., Consler, T.G., Stimmel, J.B., Goodwin, B., Liddle, C., Blanchard, S.G., Willson, T.M., Collins, J.L., Kliewer, S.A. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Choi, E., Lee, S., Yeom, S.Y., Kim, G.H., Lee, J.W., Kim, S.W. Mol. Endocrinol. (2005) [Pubmed]
  4. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Lempiäinen, H., Molnár, F., Macias Gonzalez, M., Peräkylä, M., Carlberg, C. Mol. Endocrinol. (2005) [Pubmed]
  5. Constitutive Androstane Receptor (CAR) as a Potential Sensing Biomarker of Persistent Organic Pollutants (POPs) in Aquatic Mammal: Molecular Characterization, Expression Level, and Ligand Profiling in Baikal Seal (Pusa sibirica). Sakai, H., Iwata, H., Kim, E.Y., Tsydenova, O., Miyazaki, N., Petrov, E.A., Batoev, V.B., Tanabe, S. Toxicol. Sci. (2006) [Pubmed]
  6. Orientation and vertical fluctuations of spin-labeled analogues of cholesterol and androstanol in phospholipid bilayers. Morrot, G., Bureau, J.F., Roux, M., Maurin, L., Favre, E., Devaux, P.F. Biochim. Biophys. Acta (1987) [Pubmed]
  7. Comparative study of the lipid dynamics in the surface layer of porcine and human high density lipoprotein subclasses by spin labeling. Nöthig-Laslo, V., Knipping, G. Chem. Phys. Lipids (1985) [Pubmed]
 
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