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Chemical Compound Review:

SureCN219161 (8R,9S,10R,13S,14S)-10,13- dimethyl-1,2,6,7...

Synonyms: AG-F-44705, AG-H-18818, CTK1D7814, NSC 93234, FT-0662144, ...

Cooke, G.M., Kwan, T.K. et al., Bensafi, M. et al., Jacob, S. et al., Lundström, J.N. et al.

Bensafi, Tsutsui, Khan, Levenson, Sobel, Lundström, Hummel, Olsson,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on NSC 93234

Individual differences in sensitivity to the odor of 4,16-androstadien-3-one [1].

High impact information on NSC 93234

The effects of sniffing different concentrations of the human sex-steroid derived compound 4,16-androstadien-3-one (AND) on autonomic nervous system function and mood were measured in 60 subjects [2].
Pregnenolone was converted into 5,16-androstadien-3 beta-ol, 4,16-androstadien-3-one, 5 alpha-androst-16-en-3-one and 5 alpha-androst-16-en-3 alpha- and 3 beta-ols, but the quantities were some 50 times less than those formed in the mature boar testis [3].
The human chemosignal, Delta 4,16-androstadien-3-one modulates psychological state without being consciously discernible as an odor [4].
When cells from both age groups were incubated with [14C]- or [3H]-pregnenolone (360 and 3.0 nmol/l), 17-hydroxypregnenolone (15%) and DHEA (5-10%) were the major metabolites on the androgen pathway and 5,16-androstadien-3 beta-ol (andien-beta, 5-10%) and 4,16-androstadien-3-one (dienone, 5-10%) on the 16-androstene pathway [5].

References

Individual differences in sensitivity to the odor of 4,16-androstadien-3-one. Lundström, J.N., Hummel, T., Olsson, M.J. Chem. Senses (2003) [Pubmed]
Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner. Bensafi, M., Tsutsui, T., Khan, R., Levenson, R.W., Sobel, N. Psychoneuroendocrinology (2004) [Pubmed]
Biosynthesis of androgens and pheromonal steroids in neonatal porcine testicular preparations. Kwan, T.K., Orengo, C., Gower, D.B. FEBS Lett. (1985) [Pubmed]
Sustained human chemosignal unconsciously alters brain function. Jacob, S., Kinnunen, L.H., Metz, J., Cooper, M., McClintock, M.K. Neuroreport (2001) [Pubmed]
Steroidogenesis in interstitial cells and microsomal fraction of immature pig testes. Cooke, G.M. J. Reprod. Fertil. (1991) [Pubmed]

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