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Chemical Compound Review

17-Hydroxypregnenolone     1- [(3S,8R,9S,10R,13S,14S,17R)- 3,17...

Synonyms: CHEMBL408706, SureCN735471, CHEBI:28750, HMDB00363, LMST02030089, ...
 
 
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Disease relevance of 17-Hydroxypregnenolone

 

High impact information on 17-Hydroxypregnenolone

 

Biological context of 17-Hydroxypregnenolone

 

Anatomical context of 17-Hydroxypregnenolone

 

Associations of 17-Hydroxypregnenolone with other chemical compounds

 

Gene context of 17-Hydroxypregnenolone

 

Analytical, diagnostic and therapeutic context of 17-Hydroxypregnenolone

References

  1. Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period. Riepe, F.G., Mahler, P., Sippell, W.G., Partsch, C.J. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  2. Pre- and postpuberal findings in premature adrenarche. DiMartino-Nardi, J. Journal of pediatric endocrinology & metabolism : JPEM. (2000) [Pubmed]
  3. The roles of insulin sensitivity, insulin-like growth factor I (IGF-I), and IGF-binding protein-1 and -3 in the hyperandrogenism of African-American and Caribbean Hispanic girls with premature adrenarche. Vuguin, P., Linder, B., Rosenfeld, R.G., Saenger, P., DiMartino-Nardi, J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  4. Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes. Lee, T.C., Miller, W.L., Auchus, R.J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  5. Adrenal androgen excess in women: lack of a role for 17-hydroxylase and 17,20-lyase dysregulation. Azziz, R., Bradley, E.L., Potter, H.D., Boots, L.R. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  6. Adrenal steroidogenesis in very low birth weight preterm infants. Hingre, R.V., Gross, S.J., Hingre, K.S., Mayes, D.M., Richman, R.A. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  7. Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response. Lazar, L., Kauli, R., Bruchis, C., Nordenberg, J., Galatzer, A., Pertzelan, A. Eur. J. Endocrinol. (1995) [Pubmed]
  8. Synthesis of (19E)-3 beta,17-dihydroxy-20-oxopregn-5-en-19-al 19-(O-carboxymethyl)oxime, new steroidal hapten for 17-hydroxypregnenolone. Pouzar, V., Fajkos, J. Steroids (1994) [Pubmed]
  9. 17-Hydroxylase and andien-beta synthetase activities in immature pig testis microsomal fraction: kinetic studies of the pregnenolone binding site and possible intermediates of the reactions. Lavallée, J., Cooke, G.M. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  10. Determination of 17alpha-hydroxypregnenolone sulfate and its application in diagnostics. Vceláková, H., Hill, M., Lapcík, O., Parízek, A. Steroids (2007) [Pubmed]
  11. Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects. Hill, M., Lukác, D., Lapcík, O., Sulcová, J., Hampl, R., Pouzar, V., Stárka, L. Clin. Chem. Lab. Med. (1999) [Pubmed]
  12. Unconjugated and sulfoconjugated steroids in plasma and zones of the adrenal cortex of the guinea pig. Nishikawa, T., Strott, C.A. Steroids (1983) [Pubmed]
  13. Age-related changes in serum 17-hydroxypregnenolone and 17-hydroxypregnenolone sulfate concentrations in human infancy and childhood. Shimozawa, K., Saisho, S., Yata, J., Kambegawa, A. Endocrinol. Jpn. (1988) [Pubmed]
  14. The control of steroidogenesis by human fetal adrenal cells in tissue culture. I. Responses to adrenocorticotropin. Fujieda, K., Faiman, C., Reyes, F.I., Winter, J.S. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  15. Impaired glucocorticoid synthesis in premature infants developing chronic lung disease. Watterberg, K.L., Gerdes, J.S., Cook, K.L. Pediatr. Res. (2001) [Pubmed]
  16. Influence of age and endocrine factors on the volume of benign prostatic hyperplasia. Partin, A.W., Oesterling, J.E., Epstein, J.I., Horton, R., Walsh, P.C. J. Urol. (1991) [Pubmed]
  17. Identification of 16-dehydropregnenolone as an intermediate in 16-androstene biosynthesis in neonatal porcine testicular microsomes. Kwan, T.K., Taylor, N.F., Watson, D., Gower, D.B. FEBS Lett. (1984) [Pubmed]
  18. Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls. Marui, S., Castro, M., Latronico, A.C., Elias, L.L., Arnhold, I.J., Moreira, A.C., Mendonca, B.B. Clin. Endocrinol. (Oxf) (2000) [Pubmed]
  19. The effect of serum prolactin on plasma adrenal androgens and the production and metabolic clearance rate of dehydroepiandrosterone sulfate in normal and hyperprolactinemic subjects. Schiebinger, R.J., Chrousos, G.P., Cutler, G.B., Loriaux, D.L. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  20. Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase. Soucy, P., Lacoste, L., Luu-The, V. Eur. J. Biochem. (2003) [Pubmed]
  21. Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome. Lobo, R.A., Goebelsmann, U. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  22. Plasma 17-OH pregnenolone: comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine. Fiet, J., Giton, F., Boudi, A., Boudou, P., Soliman, H., Villette, J., Galons, H. Steroids (2001) [Pubmed]
 
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