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Chemical Compound Review

AG-F-26115     2-methylidenepentanedioic acid

Synonyms: CHEBI:17207, NSC-21369, AC1L3TOU, NSC21369, KB-25112, ...
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Disease relevance of NSC21369


High impact information on NSC21369


Chemical compound and disease context of NSC21369


Associations of NSC21369 with other chemical compounds

  • The results demonstrate that 2-methyleneglutarate mutase catalyses the reversible migration of an acryloyl residue from the alpha-carbon to the beta-carbon of propionate with inversion of configuration at the alpha-carbon [8].

Analytical, diagnostic and therapeutic context of NSC21369


  1. Rotation of the exo-methylene group of (R)-3-methylitaconate catalyzed by coenzyme B(12)-dependent 2-methyleneglutarate mutase from Eubacterium barkeri. Pierik, A.J., Ciceri, D., Bröker, G., Edwards, C.H., McFarlane, W., Winter, J., Buckel, W., Golding, B.T. J. Am. Chem. Soc. (2002) [Pubmed]
  2. Studying the signaling role of 2-oxoglutaric acid using analogs that mimic the ketone and ketal forms of 2-oxoglutaric acid. Chen, H., Laurent, S., Bédu, S., Ziarelli, F., Chen, H.L., Cheng, Y., Zhang, C.C., Peng, L. Chem. Biol. (2006) [Pubmed]
  3. Cloning, sequencing and expression of the gene encoding the coenzyme B12-dependent 2-methyleneglutarate mutase from Clostridium barkeri in Escherichia coli. Beatrix, B., Zelder, O., Linder, D., Buckel, W. Eur. J. Biochem. (1994) [Pubmed]
  4. Searching for intermediates in the carbon skeleton rearrangement of 2-methyleneglutarate to (R)-3-methylitaconate catalyzed by coenzyme B12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri. Pierik, A.J., Ciceri, D., Lopez, R.F., Kroll, F., Bröker, G., Beatrix, B., Buckel, W., Golding, B.T. Biochemistry (2005) [Pubmed]
  5. A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase. Huhta, M.S., Ciceri, D., Golding, B.T., Marsh, E.N. Biochemistry (2002) [Pubmed]
  6. Coenzyme B12-dependent 2-methyleneglutarate mutase from Clostridium barkeri. Protection by the substrate from inactivation by light. Michel, C., Buckel, W. FEBS Lett. (1991) [Pubmed]
  7. On the role of two different cobalt(II) species in coenzyme B12-dependent 2-methyleneglutarate mutase from Clostridium barkeri. Zelder, O., Buckel, W. Biol. Chem. Hoppe-Seyler (1993) [Pubmed]
  8. On the steric course of the adenosylcobalamin-dependent 2-methyleneglutarate mutase reaction in Clostridium barkeri. Hartrampf, G., Buckel, W. Eur. J. Biochem. (1986) [Pubmed]
  9. Purification of the coenzyme B12-containing 2-methyleneglutarate mutase from Clostridium barkeri by high-performance liquid chromatography. Michel, C., Buckel, W., Linder, D. J. Chromatogr. (1991) [Pubmed]
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