Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ABCA9 - ATP-binding cassette, sub-family A (ABC1),...

Homo sapiens

Synonyms: ATP-binding cassette sub-family A member 9, EST640918

Piehler, A. et al., Wakaumi, M. et al.

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High impact information on ABCA9

Here, we report the molecular cloning of an additional ABC A subfamily transporter from macrophages denoted ABCA9 [1].
Based on this information, ABCA9 is likely involved in monocyte differentiation and macrophage lipid homeostasis [1].
Analysis of the genomic structure revealed that the ABCA9 gene consists of 39 exons that are located within a genomic region of approximately 85 kb size on chromosome 17q24 [1].
Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9 [1].
Similar reductions in ABCA5, ABCA7, ABCA8b and ABCA9 mRNA were also observed [2].

Anatomical context of ABCA9

We identified alternative ABCA9 mRNA variants in human macrophages that predict the existence of three truncated forms of the novel transporter [1].

References

Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9. Piehler, A., Kaminski, W.E., Wenzel, J.J., Langmann, T., Schmitz, G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi, M., Ishibashi, K., Ando, H., Kasanuki, H., Tsuruoka, S. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]

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