Gene Review:
TDO2 - tryptophan 2,3-dioxygenase
Homo sapiens
Synonyms:
TDO, TO, TPH2, TRPO, Tryptamin 2,3-dioxygenase, ...
- Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer. Chung, K.T., Fulk, G.E., Slein, M.W. J. Natl. Cancer Inst. (1975)
- Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver. Kappas, A., Drummond, G.S., Sardana, M.K. J. Clin. Invest. (1985)
- Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Forouhar, F., Anderson, J.L., Mowat, C.G., Vorobiev, S.M., Hussain, A., Abashidze, M., Bruckmann, C., Thackray, S.J., Seetharaman, J., Tucker, T., Xiao, R., Ma, L.C., Zhao, L., Acton, T.B., Montelione, G.T., Chapman, S.K., Tong, L. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Tryptophanase in sRNA control of the Escherichia coli cell cycle. Chattoraj, D.K. Mol. Microbiol. (2007)
- Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior. Brett, P.M., Curtis, D., Robertson, M.M., Gurling, H.M. The American journal of psychiatry. (1995)
- Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. Nabi, R., Serajee, F.J., Chugani, D.C., Zhong, H., Huq, A.H. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004)
- Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Miller, C.L., Llenos, I.C., Dulay, J.R., Weis, S. Brain Res. (2006)
- Predisposition to alcoholism, tryptophan oxygenase activity, and structure of intron 6 in the corresponding gene of C57BL/6J, CC57BR/Mv, and BALB/cJ mice. Kaledin, V.I., Klimova, N.V., Vasil'ev, G.V., Ivanova, E.A., Vasil'eva, E.D., Il'nitskaya, S.I. Bull. Exp. Biol. Med. (2003)
- TPH2: an answer for unipolar depression? Slow, E. Clin. Genet. (2005)
- Abnormal tryptophan metabolism in a family with a history of bladder cancer. Leklem, J.E., Brown, R.R. J. Natl. Cancer Inst. (1976)
- Distribution of intrinsic factor-vitamin B12 receptors in human intestine. Hagedorn, C.H., Alpers, D.H. Gastroenterology (1977)
- Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Saito, K., Fujigaki, S., Heyes, M.P., Shibata, K., Takemura, M., Fujii, H., Wada, H., Noma, A., Seishima, M. Am. J. Physiol. Renal Physiol. (2000)
- Increase in tryptophan oxygenase activity in alcoholic patients. Buydens-Branchey, L., Branchey, M., Worner, T.M., Zucker, D., Aramsombatdee, E., Lieber, C.S. Alcohol. Clin. Exp. Res. (1988)
- Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Wu, Z.L., Aryal, P., Lozach, O., Meijer, L., Guengerich, F.P. Chem. Biodivers. (2005)
- Dioxygenase-catalysed oxidation of disubstituted benzene substrates: benzylic monohydroxylation versus aryl cis-dihydroxylation and the meta effect. Boyd, D.R., Sharma, N.D., Bowers, N.I., Dalton, H., Garrett, M.D., Harrison, J.S., Sheldrake, G.N. Org. Biomol. Chem. (2006)
- Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. Comings, D.E., Muhleman, D., Dietz, G., Sherman, M., Forest, G.L. Genomics (1995)
- Point mutations within 663-666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY-1 transcription factor binding site. Vasiliev, G.V., Merkulov, V.M., Kobzev, V.F., Merkulova, T.I., Ponomarenko, M.P., Kolchanov, N.A. FEBS Lett. (1999)
- Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders. Comings, D.E., Muhleman, D., Dietz, G.W., Donlon, T. Genomics (1991)
- Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. Okaya, A., Kitanaka, J., Kitanaka, N., Satake, M., Kim, Y., Terada, K., Sugiyama, T., Takemura, M., Fujimoto, J., Terada, N., Miyajima, A., Tsujimura, T. Am. J. Pathol. (2005)
- Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Wirleitner, B., Neurauter, G., Schröcksnadel, K., Frick, B., Fuchs, D. Current medicinal chemistry. (2003)
- Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits. Allegri, G., Ragazzi, E., Costa, C.V., Caparrotta, L., Biasiolo, M., Comai, S., Bertazzo, A. Clin. Chim. Acta (2004)
- Monitoring tryptophan metabolism in chronic immune activation. Schröcksnadel, K., Wirleitner, B., Winkler, C., Fuchs, D. Clin. Chim. Acta (2006)
- Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues. Dick, R., Murray, B.P., Reid, M.J., Correia, M.A. Arch. Biochem. Biophys. (2001)
- Mutation of an active site residue of tryptophan synthase (beta-serine 377) alters cofactor chemistry. Jhee, K.H., Yang, L.H., Ahmed, S.A., McPhie, P., Rowlett, R., Miles, E.W. J. Biol. Chem. (1998)
- Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Miller, C.L., Llenos, I.C., Dulay, J.R., Barillo, M.M., Yolken, R.H., Weis, S. Neurobiol. Dis. (2004)
- Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons. Salli, U., Reddy, A.P., Salli, N., Lu, N.Z., Kuo, H.C., Pau, F.K., Wolf, D.P., Bethea, C.L. Exp. Neurol. (2004)
- Repression of GR-mediated expression of the tryptophan oxygenase gene by the SWI/SNF complex during liver development. Inayoshi, Y., Kaneoka, H., Machida, Y., Terajima, M., Dohda, T., Miyake, K., Iijima, S. J. Biochem. (2005)
- Cancer cachexia and depressive states: a neuro-endocrine-immunological disease? Iwagaki, H., Hizuta, A., Uomoto, M., Takeuchi, Y., Saito, S., Tanaka, N. Acta Med. Okayama (1997)
- A new metabolic pathway for N,N-dimethyltryptamine. Hryhorczuk, L.M., Rainey, J.M., Frohman, C.E., Novak, E.A. Biol. Psychiatry (1986)
- Cloning and characterization of the Tribolium castaneum eye-color genes encoding tryptophan oxygenase and kynurenine 3-monooxygenase. Lorenzen, M.D., Brown, S.J., Denell, R.E., Beeman, R.W. Genetics (2002)
- Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells. Mizuguchi, T., Hui, T., Palm, K., Sugiyama, N., Mitaka, T., Demetriou, A.A., Rozga, J. J. Cell. Physiol. (2001)
- The effects of oestrogen administration on tryptophan metabolism in rats and in menopausal women receiving hormone replacement therapy. Bender, D.A., Laing, A.E., Vale, J.A., Papadaki, L., Pugh, M. Biochem. Pharmacol. (1983)