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Gene Review:

CACNG2 - calcium channel, voltage-dependent, gamma...

Homo sapiens

Synonyms: MGC138502, MGC138504, Neuronal voltage-gated calcium channel gamma-2 subunit, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, ...

Burgess, D.L. et al., Burgess, D.L. et al., Silberberg, G. et al.

Burgess, Gefrides, Ashizawa, Burgess, Noebels, Noebels, Matsuura, Davis,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CACNG2

Because gene duplication often generates paralogs that remain in close syntenic proximity (tandem duplication) or are copied onto related daughter chromosomes (chromosome or whole-genome duplication), we hypothesized that the known positions of CACNG1 and CACNG2 could be used to predict the likely locations of additional gamma subunit genes [1].
Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13 [2].
CONCLUSIONS: Here we report the first genetic linkage of CACNG2 on chromosome 22q13 and exclude it as a candidate for SCA10 [2].
METHODS: Polymerase chain reaction (PCR) based assays were developed for two polymorphic microsatellite markers near CACNG2 [2].

Associations of CACNG2 with chemical compounds

Our findings suggest that Stargazin dysregulation may be involved with the pathophysiology of BPD, but not with that of schizophrenia, and that Stargazin polymorphisms may play a role in the response to lithium treatment [3].

Biological context of CACNG2

The location of CACNG2 was determined by linkage and haplotype analysis of the genotypes of 22 individuals from a human pedigree segregating SCA10 [2].

References

Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Burgess, D.L., Davis, C.F., Gefrides, L.A., Noebels, J.L. Genome Res. (1999) [Pubmed]
Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13. Burgess, D.L., Matsuura, T., Ashizawa, T., Noebels, J.L. Epilepsia (2000) [Pubmed]
Stargazin involvement with bipolar disorder and response to lithium treatment. Silberberg, G., Levit, A., Collier, D., St Clair, D., Munro, J., Kerwin, R.W., Tondo, L., Floris, G., Breen, G., Navon, R. Pharmacogenet. Genomics (2008) [Pubmed]

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CACNG2	Bos taurus
CACNG2	Canis lupus familiaris
cacng2a	Danio rerio
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cacng2	Xenopus (Silurana) tropicalis

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