Disease relevance of motB

• We determined the torque of the flagellar motor of Caulobacter crescentus for different motor rotation rates by measuring the rotation rate and swimming speed of the cell body and found it to be remarkably different from that of other bacteria, such as Escherichia coli and Vibrio alginolyticus [1].
• The average stall torque of the Caulobacter flagellar motor was approximately 350 pN nm, much smaller than the values of the other bacteria measured [1].

High impact information on motB

• Cells of a motB strain carrying plasmids in which transcription of the wild-type motB gene was controlled by the lac promoter were tethered to a glass surface by a single flagellum [2].
• The motA and motB gene products are found in the cytoplasmic membrane; they do not co-purify with flagellar basal bodies isolated in neutral detergents [2].
• The 15th suppressor from the original selection and 2 motB suppressors identified during a subsequent search cause single amino acid substitutions in FliG [3].
• To study interactions between the Mot proteins themselves and between them and other components of the flagellar motor, we attempted to isolate extragenic suppressors of 13 dominant or partially dominant motB missense mutations [3].
• Two open reading frames that exhibited sequence similarity to the Escherichia coli and B. subtilis motA and motB motility genes were found immediately downstream from ccpA; disruption of this region had no effect on growth, sporulation or motility [4].

Chemical compound and disease context of motB

• Low Flagellar Motor Torque and High Swimming Efficiency of Caulobacter crescentus Swarmer Cells [1].
• The motility genes motA and motB of Escherichia coli were placed under control of the Serratia marcescens trp promoter [5].

References