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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rnrb  -  ribosomal RNA, fragment B

Mus musculus

 
 
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High impact information on Rnrb

  • Restriction digest patterns of high renin strains (Rnrs) are characteristically distinct from patterns observed for low renin strains (Rnrb) and are suggestive of a structural gene duplication at the chromosome 1 locus in high renin strains [1].
  • However, gene dosage cannot account for the increased levels in high renin strains, since SMG renin levels in Rnrs and those in Rnrb may differ up to 100-fold [1].
  • Strains carrying the Rnrb allele, such as BALB/c or C57 Bl/6, or CH3 mice, have one renin structural gene per haploid genome, while those having the Rnrs allele, such as AKR or Swiss mice, have two renin genes [2].
  • Mice homozygous for Rnrs or Rnrb alleles have high or low levels of submaxillary gland renin, respectively [3].
  • Female SWR/J mice (Rnrs/Rnrs) have 1000-fold higher submandibular gland renin activity than C57BL/6J mice (Rnrb/Rnrb) [4].

References

  1. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Piccini, N., Knopf, J.L., Gross, K.W. Cell (1982) [Pubmed]
  2. The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication. Panthier, J.J., Holm, I., Rougeon, F. EMBO J. (1982) [Pubmed]
  3. Genetic regulation of thermostability of mouse submaxillary gland renin. Wilson, C.M., Taylor, B.A. J. Biol. Chem. (1982) [Pubmed]
  4. Comparison of genetic and endocrine control of renin and kallikrein in mouse submandibular gland. Wilson, C.M., Reynolds, R.C., Ward, P.E. Life Sci. (1982) [Pubmed]
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