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Gene Review

Rnrb  -  ribosomal RNA, fragment B

Mus musculus

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High impact information on Rnrb

  • Restriction digest patterns of high renin strains (Rnrs) are characteristically distinct from patterns observed for low renin strains (Rnrb) and are suggestive of a structural gene duplication at the chromosome 1 locus in high renin strains [1].
  • However, gene dosage cannot account for the increased levels in high renin strains, since SMG renin levels in Rnrs and those in Rnrb may differ up to 100-fold [1].
  • Strains carrying the Rnrb allele, such as BALB/c or C57 Bl/6, or CH3 mice, have one renin structural gene per haploid genome, while those having the Rnrs allele, such as AKR or Swiss mice, have two renin genes [2].
  • Mice homozygous for Rnrs or Rnrb alleles have high or low levels of submaxillary gland renin, respectively [3].
  • Female SWR/J mice (Rnrs/Rnrs) have 1000-fold higher submandibular gland renin activity than C57BL/6J mice (Rnrb/Rnrb) [4].


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