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Gene Review:

TADA3 - transcriptional adaptor 3

Homo sapiens

Synonyms: ADA3, ADA3 homolog, ADA3-like protein, FLJ20221, FLJ21329, ...

Meng, G. et al., Zeng, M. et al., Brand, M. et al., Wang, T. et al., Nag, A. et al.

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High impact information on TADA3L

Proper hADA3 function is essential for full transcriptional activity of p53 and p53-mediated apoptosis [1].
An Essential Role of Human Ada3 in p53 Acetylation [2].
Using the chromatin immunoprecipitation assay, we also show that hADA3 is a component of the activator complexes bound to the native ER response element within the promoter of the estrogen-responsive gene pS2 [3].
Using ectopic expression approaches, we further demonstrated that hADA3 directly binds to the 9-cis retinoic acid receptors alpha and beta, and functions as a coactivator for retinoid receptor-mediated transcriptional activation [3].
Using chromatin immunoprecipitation, we show that hADA3 is part of activator complexes bound to the native RXR response elements within the promoter of the cyclin-dependent kinase inhibitor gene p21 [4].

Associations of TADA3L with chemical compounds

We show that hADA3 enhances the RXR(alpha)-mediated sequence-specific transactivation of retinoid target genes, cellular retinoic acid-binding protein II and p21 [4].

Other interactions of TADA3L

Furthermore, we identified four other previously uncharacterized subunits of TFTC: hADA3, hTAFII150, hSPT3, and hPAF65beta [5].

References

hADA3 is required for p53 activity. Wang, T., Kobayashi, T., Takimoto, R., Denes, A.E., Snyder, E.L., el-Deiry, W.S., Brachmann, R.K. EMBO J. (2001) [Pubmed]
An Essential Role of Human Ada3 in p53 Acetylation. Nag, A., Germaniuk-Kurowska, A., Dimri, M., Sassack, M.A., Gurumurthy, C.B., Gao, Q., Dimri, G., Band, H., Band, V. J. Biol. Chem. (2007) [Pubmed]
Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. Meng, G., Zhao, Y., Nag, A., Zeng, M., Dimri, G., Gao, Q., Wazer, D.E., Kumar, R., Band, H., Band, V. J. Biol. Chem. (2004) [Pubmed]
Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. Zeng, M., Kumar, A., Meng, G., Gao, Q., Dimri, G., Wazer, D., Band, H., Band, V. J. Biol. Chem. (2002) [Pubmed]
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. Brand, M., Yamamoto, K., Staub, A., Tora, L. J. Biol. Chem. (1999) [Pubmed]

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TADA3	Canis lupus familiaris
tada3l	Danio rerio
dik	Drosophila melanogaster
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tada3	Xenopus (Silurana) tropicalis

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