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Gene Review

VAT1  -  vesicle amine transport 1

Homo sapiens

Synonyms: FLJ20230, Synaptic vesicle membrane protein VAT-1 homolog, VATI
 
 
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Disease relevance of VAT1

 

High impact information on VAT1

  • CONCLUSIONS: Our results indicate that hVAT-1 exerts a specific function in keratinocyte physiology, in particular in calcium-regulated processes, with no evident deregulation in malignancies of the breast and ovary [1].
  • Normal and malignant mammary and ovary epithelium were found to be hVAT-1-negative [1].
  • BACKGROUND AND AIMS: Human VAT-1 (hVAT-1) is a homologue of the synaptic vesicle membrane protein of Torpedo californica [1].
  • Human VAT-1: a calcium-regulated activation marker of human epithelial cells [1].
  • However, the hVAT-1 protein expression pattern in normal epithelial tissues such as skin, mammary gland and ovary, as well as in tumours of the mammary gland and ovary, has not been studied [1].
 

Associations of VAT1 with chemical compounds

  • An ayurvedic contraceptive--pippaliyadi vati, containing equal parts of powdered seeds or fruit berries of Embelia ribes, fruit of Piper longum and borax powder was fed orally to two groups of pregnant rats: 2.5 times to one and five times to the other; the recommended dose for humans [2].

References

  1. Human VAT-1: a calcium-regulated activation marker of human epithelial cells. Koch, J., Foekens, J., Timmermans, M., Fink, W., Wirzbach, A., Kramer, M.D., Schaefer, B.M. Arch. Dermatol. Res. (2003) [Pubmed]
  2. Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive--pippaliyadi vati. Chaudhury, M.R., Chandrasekaran, R., Mishra, S. Journal of ethnopharmacology. (2001) [Pubmed]
 
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