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Gene Review:

TRIM3 - tripartite motif containing 3

Homo sapiens

Synonyms: BERP, Brain-expressed RING finger protein, HAC1, RING finger protein 22, RING finger protein 97, ...

El-Husseini, A.E. et al., El-Husseini, A.E. et al., van Diepen, M.T. et al., El-Husseini, A.E. et al., Yan, Q. et al.

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High impact information on TRIM3

CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling [1].
This interaction was confirmed by immunoprecipitation, which also demonstrated that BERP could associate with myosin Va, the product of the dilute gene [2].
We also found that the RBCC domain of BERP is involved in protein dimerization [2].
Like myosin Va, BERP is expressed in a punctate pattern in the cytoplasm as well as in the neurites and growth cones of PC12 cells [2].
BERP is highly expressed in brain and contains an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil (RBCC domain), and a unique C-terminal beta-propeller domain [2].

Biological context of TRIM3

Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5 [3].
Screening of a rat brain cDNA library identified alpha-actinin-4 as a specific binding partner for the N-terminus of BERP [4].

Other interactions of TRIM3

The tripartite motif proteins TRIM-2 and TRIM-3 have been put forward as putative organizers of neuronal outgrowth and structural plasticity [5].

References

CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. Yan, Q., Sun, W., Kujala, P., Lotfi, Y., Vida, T.A., Bean, A.J. Mol. Biol. Cell (2005) [Pubmed]
Cloning and characterization of a novel RING finger protein that interacts with class V myosins. El-Husseini, A.E., Vincent, S.R. J. Biol. Chem. (1999) [Pubmed]
Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. El-Husseini, A.E., Fretier, P., Vincent, S.R. Genomics (2001) [Pubmed]
BERP, a novel ring finger protein, binds to alpha-actinin-4. El-Husseini, A.E., Kwasnicka, D., Yamada, T., Hirohashi, S., Vincent, S.R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
The molluscan RING-finger protein L-TRIM is essential for neuronal outgrowth. van Diepen, M.T., Spencer, G.E., van Minnen, J., Gouwenberg, Y., Bouwman, J., Smit, A.B., van Kesteren, R.E. Mol. Cell. Neurosci. (2005) [Pubmed]

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TRIM3	Bos taurus
TRIM3	Canis lupus familiaris
trim3a	Danio rerio
trim3b	Danio rerio
TRIM3	Gallus gallus
TRIM3	Macaca mulatta
Trim3	Mus musculus
TRIM3	Pan troglodytes
Trim3	Rattus norvegicus

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