Gene Review:
HGS - hepatocyte growth factor-regulated...
Homo sapiens
Synonyms:
HRS, Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, Vps27, ...
- The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility. Gutmann, D.H., Haipek, C.A., Burke, S.P., Sun, C.X., Scoles, D.R., Pulst, S.M. Hum. Mol. Genet. (2001)
- The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Scoles, D.R., Huynh, D.P., Chen, M.S., Burke, S.P., Gutmann, D.H., Pulst, S.M. Hum. Mol. Genet. (2000)
- The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Bache, K.G., Slagsvold, T., Cabezas, A., Rosendal, K.R., Raiborg, C., Stenmark, H. Mol. Biol. Cell (2004)
- Hrs function: viruses provide the clue. Clague, M.J., Urbé, S. Trends Cell Biol. (2003)
- HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. Pornillos, O., Higginson, D.S., Stray, K.M., Fisher, R.D., Garrus, J.E., Payne, M., He, G.P., Wang, H.E., Morham, S.G., Sundquist, W.I. J. Cell Biol. (2003)
- Comparison of Vivalan (viloxazine hydrochloride) with imipramine in the treatment of depression. A double-blind study. Santonastaso, P., Maistrello, I., Battistin, L. Acta psychiatrica Scandinavica. (1979)
- Factorial structure and factor reliability of the Hamilton Rating Scale for Depression. O'Brien, K.P., Glaudin, V. Acta psychiatrica Scandinavica. (1988)
- Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Hicke, L., Dunn, R. Annu. Rev. Cell Dev. Biol. (2003)
- Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Misra, S., Puertollano, R., Kato, Y., Bonifacino, J.S., Hurley, J.H. Nature (2002)
- Ca2+ and N-ethylmaleimide-sensitive factor differentially regulate disassembly of SNARE complexes on early endosomes. Yan, Q., Sun, W., McNew, J.A., Vida, T.A., Bean, A.J. J. Biol. Chem. (2004)
- Renal eicosanoids as determinants of renal function in liver disease. Epstein, M., Lifschitz, M. Hepatology (1987)
- The course of type 1 hepato-renal syndrome post liver transplantation. Marik, P.E., Wood, K., Starzl, T.E. Nephrol. Dial. Transplant. (2006)
- Endothelin and nitric oxide in hepatorenal syndrome: a balance reset. Epstein, M., Goligorsky, M.S. J. Nephrol. (1997)
- TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. Seroussi, E., Kedra, D., Kost-Alimova, M., Sandberg-Nordqvist, A.C., Fransson, I., Jacobs, J.F., Fu, Y., Pan, H.Q., Roe, B.A., Imreh, S., Dumanski, J.P. Genomics (1999)
- TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Lu, Q., Hope, L.W., Brasch, M., Reinhard, C., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. Chin, L.S., Raynor, M.C., Wei, X., Chen, H.Q., Li, L. J. Biol. Chem. (2001)
- STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. Bache, K.G., Raiborg, C., Mehlum, A., Stenmark, H. J. Biol. Chem. (2003)
- Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura, K. J. Biol. Chem. (2005)
- Association with Hrs is required for the early endosomal localization, stability, and function of STAM. Mizuno, E., Kawahata, K., Okamoto, A., Kitamura, N., Komada, M. J. Biochem. (2004)
- Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. Sun, W., Yan, Q., Vida, T.A., Bean, A.J. J. Cell Biol. (2003)
- PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. Petiot, A., Faure, J., Stenmark, H., Gruenberg, J. J. Cell Biol. (2003)
- A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. O'Hanlon, T.P., Raben, N., Miller, F.W. Biochem. Biophys. Res. Commun. (1995)
- Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Scoles, D.R., Nguyen, V.D., Qin, Y., Sun, C.X., Morrison, H., Gutmann, D.H., Pulst, S.M. Hum. Mol. Genet. (2002)
- An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Gullapalli, A., Wolfe, B.L., Griffin, C.T., Magnuson, T., Trejo, J. Mol. Biol. Cell (2006)
- STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mizuno, E., Kawahata, K., Kato, M., Kitamura, N., Komada, M. Mol. Biol. Cell (2003)
- Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. Komada, M., Masaki, R., Yamamoto, A., Kitamura, N. J. Biol. Chem. (1997)
- A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor. Morino, C., Kato, M., Yamamoto, A., Mizuno, E., Hayakawa, A., Komada, M., Kitamura, N. Exp. Cell Res. (2004)
- Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Razi, M., Futter, C.E. Mol. Biol. Cell (2006)
- CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. Yan, Q., Sun, W., Kujala, P., Lotfi, Y., Vida, T.A., Bean, A.J. Mol. Biol. Cell (2005)
- Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. Row, P.E., Clague, M.J., Urbé, S. Biochem. J. (2005)
- Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. Li, Y., Chin, L.S., Levey, A.I., Li, L. J. Biol. Chem. (2002)
- Epitope studies indicate that histidyl-tRNA synthetase is a stimulating antigen in idiopathic myositis. Martin, A., Shulman, M.J., Tsui, F.W. FASEB J. (1995)
- Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. Lu, L., Komada, M., Kitamura, N. Gene (1998)