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Gene Review

RBCK1  -  RanBP-type and C3HC4-type zinc finger...

Homo sapiens

Synonyms: C20orf18, HBV-associated factor 4, HOIL-1, HOIL1, Heme-oxidized IRP2 ubiquitin ligase 1, ...
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Disease relevance of RBCK1

  • Endogenous RBCK1 protein levels increased upon phenylephrine-induced hypertrophy [1].
  • RBCK1 (RBCC protein interacting with PKC 1) has originally been identified as a protein kinase CbetaI (PKCbetaI)-binding partner by a two-hybrid screen and as one of the gene transcripts that increases during adult cardiac hypertrophy [1].

High impact information on RBCK1


Biological context of RBCK1

  • To identify protein motifs in the RBCC region of RBCK1 essential for the transcriptional activity, RBCK1 mutant proteins have been constructed and analyzed by using the GAL4 chimeric transcription regulator system [3].

Anatomical context of RBCK1

  • In this study, we showed that acute treatment of cardiac myocytes with phenylephrine, a prohypertrophic stimulant, transiently increased the association of RBCK1 with PKCbetaI within 1 min [1].
  • Red-blood-cell potassium (RBCK) as an indicator of body potassium status was measured in 103 healthy elderly subjects over the age of 65 years [4].

Associations of RBCK1 with chemical compounds


  1. RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. Vallentin, A., Mochly-Rosen, D. J. Biol. Chem. (2007) [Pubmed]
  2. Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins. Tatematsu, K., Yoshimoto, N., Koyanagi, T., Tokunaga, C., Tachibana, T., Yoneda, Y., Yoshida, M., Okajima, T., Tanizawa, K., Kuroda, S. J. Biol. Chem. (2005) [Pubmed]
  3. Transcriptional activity of RBCK1 protein (RBCC protein interacting with PKC 1): requirement of RING-finger and B-Box motifs and regulation by protein kinases. Tatematsu, K., Tokunaga, C., Nakagawa, N., Tanizawa, K., Kuroda, S., Kikkawa, U. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Red-blood-cell potassium and hand-grip strength in healthy elderly people. Bahemuka, M., Hodkinson, H.M. Age and ageing. (1976) [Pubmed]
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