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Gene Review:

ldhD - D-lactate dehydrogenase

Lactobacillus plantarum WCFS1

Taguchi, H. et al., Goffin, P. et al., Liu, S. et al., Sakai, K. et al., Ferain, T. et al.

Sakai, Fujii, Chukeatirote, Liu, Nichols, Dien, Cotta,

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Disease relevance of ldhD

13C nuclear magnetic resonance analysis of glucose and citrate end products in an ldhL-ldhD double-knockout strain of Lactobacillus plantarum [1].
A PDC gene from the Gram-positive bacterium Sarcina ventriculi (Spdc) was introduced into an LDH-deficient strain, L. plantarum TF103, in which both the ldhL and ldhD genes were inactivated [2].

High impact information on ldhD

Lactate-to-acetate conversion was not impaired in these strains, while it was completely blocked in mutants deficient in NAD-dependent lactate dehydrogenase activities, encoded by the ldhD and ldhL genes [3].
These results strongly suggest that Arg-235 plays an essential role in the tight and correct binding of substrate to the binding site of D-LDH, as in the case of Arg-171 in L-LDH [4].
Essential role of arginine 235 in the substrate-binding of Lactobacillus plantarum D-lactate dehydrogenase [4].
L. plantarum KY-1, which is isolated from model kitchen refuse, showing lactic acid racemase activity, as well as d-lactate dehydrogenase activity, in its membrane fraction [5].

References

13C nuclear magnetic resonance analysis of glucose and citrate end products in an ldhL-ldhD double-knockout strain of Lactobacillus plantarum. Ferain, T., Schanck, A.N., Delcour, J. J. Bacteriol. (1996) [Pubmed]
Metabolic engineering of a Lactobacillus plantarum double ldh knockout strain for enhanced ethanol production. Liu, S., Nichols, N.N., Dien, B.S., Cotta, M.A. J. Ind. Microbiol. Biotechnol. (2006) [Pubmed]
Major role of NAD-dependent lactate dehydrogenases in aerobic lactate utilization in Lactobacillus plantarum during early stationary phase. Goffin, P., Lorquet, F., Kleerebezem, M., Hols, P. J. Bacteriol. (2004) [Pubmed]
Essential role of arginine 235 in the substrate-binding of Lactobacillus plantarum D-lactate dehydrogenase. Taguchi, H., Ohta, T. J. Biochem. (1994) [Pubmed]
Racemization of l-lactic acid in pH-swing open fermentation of kitchen refuse by selective proliferation of Lactobacillus plantarum. Sakai, K., Fujii, N., Chukeatirote, E. J. Biosci. Bioeng. (2006) [Pubmed]

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