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Gene Review:

IGF2BP3 - insulin-like growth factor 2 mRNA binding...

Homo sapiens

Synonyms: CT98, IGF-II mRNA-binding protein 3, IGF2 mRNA-binding protein 3, IMP-3, IMP3, ...

Liao, B. et al., Sitnikova, L. et al., Gu, L. et al.

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Disease relevance of IGF2BP3

IMP-2 and IMP-3 expression levels were significantly higher in both ovarian cancer and ovarian LMP tumor samples compared to either ovarian adenomas or to normal ovary samples (p<0.05) [1].
Sixty percent of IMP3-positive patients with superficial invasive urothelial carcinoma at initial diagnosis went on to develop metastases, whereas no metastasis was found in IMP3-negative patients (P = 0.0017) [2].

High impact information on IGF2BP3

Moreover, IMP-3 knock down specifically suppressed translation of chimeric IGF-II leader-3/luciferase mRNA without altering reporter mRNA levels [3].
IMP-3 and IMP-1, two members of the IMP family with significant structural similarity, appear to have some distinct RNA targets and functions in K562 cells [3].
IMP-3 knock down also markedly inhibited cell proliferation [3].
To identify the functions of IMP-3 in target gene expression and cell proliferation, RNA interference was employed to knock down IMP-3 expression [3].
IMP-3, a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein (IMP) family, is expressed mainly during embryonic development and in some tumors [3].

Other interactions of IGF2BP3

Thus, we have identified IMP-3 as a translational activator of IGF-II leader-3 mRNA [3].

References

Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. Gu, L., Shigemasa, K., Ohama, K. Int. J. Oncol. (2004) [Pubmed]
IMP3 predicts aggressive superficial urothelial carcinoma of the bladder. Sitnikova, L., Mendese, G., Liu, Q., Woda, B.A., Lu, D., Dresser, K., Mohanty, S., Rock, K.L., Jiang, Z. Clin. Cancer Res. (2008) [Pubmed]
The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells. Liao, B., Hu, Y., Herrick, D.J., Brewer, G. J. Biol. Chem. (2005) [Pubmed]

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