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Gene Review

IGF2BP3  -  insulin-like growth factor 2 mRNA binding...

Homo sapiens

Synonyms: CT98, IGF-II mRNA-binding protein 3, IGF2 mRNA-binding protein 3, IMP-3, IMP3, ...
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Disease relevance of IGF2BP3

  • IMP-2 and IMP-3 expression levels were significantly higher in both ovarian cancer and ovarian LMP tumor samples compared to either ovarian adenomas or to normal ovary samples (p<0.05) [1].
  • Sixty percent of IMP3-positive patients with superficial invasive urothelial carcinoma at initial diagnosis went on to develop metastases, whereas no metastasis was found in IMP3-negative patients (P = 0.0017) [2].

High impact information on IGF2BP3


Other interactions of IGF2BP3

  • Thus, we have identified IMP-3 as a translational activator of IGF-II leader-3 mRNA [3].


  1. Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. Gu, L., Shigemasa, K., Ohama, K. Int. J. Oncol. (2004) [Pubmed]
  2. IMP3 predicts aggressive superficial urothelial carcinoma of the bladder. Sitnikova, L., Mendese, G., Liu, Q., Woda, B.A., Lu, D., Dresser, K., Mohanty, S., Rock, K.L., Jiang, Z. Clin. Cancer Res. (2008) [Pubmed]
  3. The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells. Liao, B., Hu, Y., Herrick, D.J., Brewer, G. J. Biol. Chem. (2005) [Pubmed]
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