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Tecr  -  trans-2,3-enoyl-CoA reductase

Mus musculus

Synonyms: 2410016D23Rik, A230102P12Rik, AI173355, D17Ertd178e, Gpsn2, ...
 
 
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Disease relevance of Gpsn2

  • During the initial stages of development, the notochord provides repulsive signals for dorsal root ganglion (DRG) axons via semaphorin 3A/neuropilin-1, axonin-1/SC2, and other unknown repulsive molecules [1].
 

High impact information on Gpsn2

  • Chemorepulsion from the ventral spinal cord does not depend on Sema3A/neuropilin-1 but requires axonin-1/SC2 to repel DRG axons [2].
  • Sequence analysis reveals some similarity between SC2 and 5 alpha-reductase, a microsomal membrane protein important in testosterone metabolism [3].
  • It is likely that the two antibodies SC3 and SC10 are directed against different linear amino acid sequences or very stable domains, whereas the third, SC2, is directed against a more fragile conformational domain of apo B [4].
  • However, apo B prepared by organic solvent, ether-ethanol, or sodium dodecyl sulfate (SDS) delipidation, while reacting strongly with SC10, is only poorly recognized by SC2 or SC3 [4].
  • SC2 did not cross-react cleanly with hair cells from the mouse or the rat but it cross-reacted with proximal tubules of the guinea-pig kidney [5].
 

Biological context of Gpsn2

  • Among 13 QTLs, three QTLs (P < 0.01) termed SC1 (located near D15Mit158) ,SC2 (DXMit140) and SC3 (DXMit64) accounted for 24%, 19% and 15% of the total variance in weight phenotype, and -3.78, 3.41 and 2.06 mg additive effect, respectively [6].
 

Analytical, diagnostic and therapeutic context of Gpsn2

  • In situ hybridization suggests that the SC2 mRNA is strongly expressed by many types of neurons [3].
  • Upon immunoblotting, some of these fragments are now recognized by either SC3 or SC10 but not SC2, some are recognized by both SC3 and SC10, and others are immunologically unreactive [4].

References

  1. Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons. Masuda, T., Fukamauchi, F., Takeda, Y., Fujisawa, H., Watanabe, K., Okado, N., Shiga, T. Mol. Cell. Neurosci. (2004) [Pubmed]
  2. Differential non-target-derived repulsive signals play a critical role in shaping initial axonal growth of dorsal root ganglion neurons. Masuda, T., Tsuji, H., Taniguchi, M., Yagi, T., Tessier-Lavigne, M., Fujisawa, H., Okado, N., Shiga, T. Dev. Biol. (2003) [Pubmed]
  3. Molecular cloning of a novel mRNA using an antibody directed against synaptic glycoproteins. Johnston, I.G., Rush, S.J., Gurd, J.W., Brown, I.R. J. Neurosci. Res. (1992) [Pubmed]
  4. Isolation and characterization of three monoclonal antibodies to human serum low density lipoprotein apoprotein B. Aggerbeck, L.P., Caron, F., Lachacinski, N., Bouma, M.E. Biochimie (1986) [Pubmed]
  5. Monoclonal antibody markers for early development of the stereociliary bundles of mammalian hair cells. Holley, M.C., Nishida, Y. J. Neurocytol. (1995) [Pubmed]
  6. Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Tan, X.L., Zhou, Y., Cai, K.F., Shao, Y.X., Zhu, S.X., Lu, L., Williams, R.W., Gu, X.S. Yi Chuan Xue Bao (2004) [Pubmed]
 
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