Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Mov14 - Moloney leukemia virus 14

Mus musculus

This record was discontinued.

Lee, J.S. et al., Jaenisch, R., Berleth, T. et al., Colombo, M.P. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mov14

In Mov-3 mice the provirus was activated shortly after birth, whereas proviruses in Mov-9 and Mov-14 were activated at different stages of embryogenesis [1].

High impact information on Mov14

All three cell types stimulated cytotoxic lymphocytes that lysed Mov-14 Con A lymphoblasts, MBL-2 and RBL-5 [2].
Transgenic Mov-14 mice, which carry the provirus of Moloney murine leukemia virus (Mo-MuLV) in the germ line and begin to produce infectious virus on embryonic day 14, were used to evaluate the ability of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to cross the placenta and protect embryos from viremia [3].
We have used the Mov-14 model previously to demonstrate the antiviral efficacy and lack of teratogenicity of transplacental therapy with 3'-azido-3'-deoxythymidine (zidovudine, ZDV) [3].
Early mouse embryos exposed to Moloney leukaemia virus (M-MuL V) produce substrains of mice, designated Mov-1 to Mov-14, that transmit the virus genetically from one generation to the next [4].

References

Activation of endogenous retroviral genomes in Mov strains of mice. Berleth, T., Nobis, P., Jaenisch, R., Harbers, K. J. Gen. Virol. (1987) [Pubmed]
Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection. Colombo, M.P., Jaenisch, R., Wettstein, P.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice. Lee, J.S., Mullaney, S., Bronson, R., Sharpe, A.H., Jaenisch, R., Balzarini, J., De Clercq, E., Ruprecht, R.M. J. Acquir. Immune Defic. Syndr. (1991) [Pubmed]
Retroviruses and mouse embryos: a model system in which to study gene expression in development and differentiation. Jaenisch, R. Ciba Found. Symp. (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.