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Chemical Compound Review

ADEFOVIR     2-(6-aminopurin-9- yl)ethoxymethylphosphoni...

Synonyms: CHEMBL484, PubChem14227, SureCN49373, AGN-PC-00FYWF, DRG-0156, ...
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Disease relevance of ADEFOVIR


High impact information on ADEFOVIR


Chemical compound and disease context of ADEFOVIR


Biological context of ADEFOVIR


Anatomical context of ADEFOVIR


Associations of ADEFOVIR with other chemical compounds


Gene context of ADEFOVIR


Analytical, diagnostic and therapeutic context of ADEFOVIR


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  20. Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells. Robbins, B.L., Greenhaw, J., Connelly, M.C., Fridland, A. Antimicrob. Agents Chemother. (1995) [Pubmed]
  21. The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines. Balzarini, J., Verstuyf, A., Hatse, S., Goebels, J., Sobis, H., Vandeputte, M., De Clercq, E. Int. J. Cancer (1995) [Pubmed]
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  25. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. Balzarini, J., Naesens, L., Slachmuylders, J., Niphuis, H., Rosenberg, I., Holý, A., Schellekens, H., De Clercq, E. AIDS (1991) [Pubmed]
  26. Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice. Lee, J.S., Mullaney, S., Bronson, R., Sharpe, A.H., Jaenisch, R., Balzarini, J., De Clercq, E., Ruprecht, R.M. J. Acquir. Immune Defic. Syndr. (1991) [Pubmed]
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  29. Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys. Cundy, K.C., Shaw, J.P., Lee, W.A. Antimicrob. Agents Chemother. (1994) [Pubmed]
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  31. Cryopreservation enables long-term storage of 9-(2-phosphonylmethoxyethyl)adenine prodrug-loaded reconstituted lactosylated high-density lipoprotein. de Vrueh, R.L., van Berkel, T.J., Bijsterbosch, M.K. Pharm. Res. (2001) [Pubmed]
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