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Gene Review

Mov1  -  Moloney leukemia virus 1

Mus musculus

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Disease relevance of Mov1


High impact information on Mov1

  • From parents heterozygous at the loci Mov1 to Mov12, respectively, homozygous offspring were obtained with the expected Mendelian frequency [6].
  • Mov-13 mice activate infectious virus during embryogenesis, leading to a distinct pattern of virus expression in all tissues of the adult, but the viral genome in Mov-1 mice is activated only during the first two weeks after birth, leading to virus expression predominantly in lymphatic organs [7].
  • Four substrains, Mov-1 to Mov-4, were derived previously [7].
  • The exogenous Moloney leukemia virus (M-MuLV) was inserted into the germ line of mice by exposing embryos to virus at different stages of embryogenesis [7].
  • A detailed comparison between Mov-1 and Mov-13 mice demonstrated that the time of virus activation is different [7].

Chemical compound and disease context of Mov1


Biological context of Mov1


Anatomical context of Mov1


Associations of Mov1 with chemical compounds


Regulatory relationships of Mov1


Other interactions of Mov1


Analytical, diagnostic and therapeutic context of Mov1


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  2. Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Niwa, O., Yokota, Y., Ishida, H., Sugahara, T. Cell (1983) [Pubmed]
  3. Distribution of murine type B and type C viral nucleic acid sequences in template active and template inactive chromatin. Howk, R.S., Anisowicz, A., Silverman, A.Y., Parks, W.P., Scoinick, E.M. Cell (1975) [Pubmed]
  4. Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems. Kiessling, R., Petranyi, G., Kärre, K., Jondal, M., Tracey, D., Wigzell, H. J. Exp. Med. (1976) [Pubmed]
  5. Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens. Weiss, A., Brunner, K.T., MacDonald, H.R., Cerottini, J.C. J. Exp. Med. (1980) [Pubmed]
  6. Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Jaenisch, R., Harbers, K., Schnieke, A., Löhler, J., Chumakov, I., Jähner, D., Grotkopp, D., Hoffmann, E. Cell (1983) [Pubmed]
  7. Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Jaenisch, R., Jähner, D., Nobis, P., Simon, I., Löhler, J., Harbers, K., Grotkopp, D. Cell (1981) [Pubmed]
  8. Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks. Fischinger, P.J., Blevins, C.S., Dunlop, N.M. Science (1978) [Pubmed]
  9. High level of tyrosine protein kinase in a murine lymphoma cell line induced by Moloney leukemia virus. Gacon, G., Gisselbrecht, S., Piau, J.P., Boissel, J.P., Tolle, J., Fischer, S. EMBO J. (1982) [Pubmed]
  10. Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene. Tabin, C.J., Hoffmann, J.W., Goff, S.P., Weinberg, R.A. Mol. Cell. Biol. (1982) [Pubmed]
  11. In vitro and in vivo characterisation of glial cells immortalised with a temperature sensitive SV40 T antigen-containing retrovirus. Jung, M., Crang, A.J., Blakemore, W.F., Hoppe, D., Kettenmann, H., Trotter, J. J. Neurosci. Res. (1994) [Pubmed]
  12. Enhancement of the antitumor activity of adriamycin by Tween 80. Casazza, A.M., Pratesi, G., Giuliani, F., Formelli, F., Di Marco, A. Tumori. (1978) [Pubmed]
  13. Moloney leukemia virus gene expression and gene amplification in preleukemic and leukemic BALB/Mo mice. Jaenisch, R. Virology (1979) [Pubmed]
  14. Immunosuppression by Moloney leukemia virus: lack of correlation between virus replication and the immunosuppressive effect. Cerny, J., Proffitt, M.R., Essex, M. J. Natl. Cancer Inst. (1976) [Pubmed]
  15. Co-transfection of normal NIH/3T3 DNA and retroval LTR sequences: a novel strategy for the detection of potential c-onc genes. Müller, R., Müller, D. EMBO J. (1984) [Pubmed]
  16. Integration of transfected LTR sequences into the c-raf proto-oncogene: activation by promoter insertion. Mölders, H., Defesche, J., Müller, D., Bonner, T.I., Rapp, U.R., Müller, R. EMBO J. (1985) [Pubmed]
  17. Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Sutcliffe, J.G., Shinnick, T.M., Verma, I.M., Lerner, R.A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  18. Germ line integration of moloney leukemia virus: effect of homozygosity at the m-mulV locus. Jaenisch, R. Cell (1977) [Pubmed]
  19. DNA methylation, retroviruses, and embryogenesis. Jaenisch, R., Harbers, K., Jähner, D., Stewart, C., Stuhlmann, H. J. Cell. Biochem. (1982) [Pubmed]
  20. Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus. McCarter, J.A., Ball, J.K., Frei, J.V. J. Natl. Cancer Inst. (1977) [Pubmed]
  21. Differentiation and virus expression in BALB/Mo mice: endogenous Moloney leukemia virus is not activated in hematopoietic cells. Fiedler, W., Nobis, P., Jähner, D., Jaenisch, R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  22. Role of divalent ion complex formation in pyran--inhibition of nucleic acid biosynthesis. Fiel, R.J., Musser, D.A., Munson, B.R. J. Natl. Cancer Inst. (1976) [Pubmed]
  23. Moloney leukemia virus-induced cell surface antigen: detection and characterization in sodium dodecyl sulfate gels. Troy, F.A., Fenyö, E.M., Klein, G. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  24. Comparison of the allospecific and viral-specific immune responses to irradiated versus formaldehyde-fixed allogeneic Moloney lymphoma cells in CBA mice. Lamon, E.W., Gatti, R.A., Kiessling, R., Fenyö, E.M. Cancer Res. (1975) [Pubmed]
  25. Lymphoid cell surface receptor for Moloney leukemia virus envelope glycoprotein gp71. II. Isolation of the receptor. Schaffar-Deshayes, L., Choppin, J., Lévy, J.P. J. Immunol. (1981) [Pubmed]
  26. Determination of the frequency of retroviral recombination between two identical sequences within a provirus. Li, T., Zhang, J. J. Virol. (2000) [Pubmed]
  27. Introduction of an activated RAS oncogene into murine bone marrow lymphoid progenitors via retroviral gene transfer results in thymic lymphomas. Dunbar, C.E., Crosier, P.S., Nienhuis, A.W. Oncogene Res. (1991) [Pubmed]
  28. Retroviruses and mouse embryos: a model system in which to study gene expression in development and differentiation. Jaenisch, R. Ciba Found. Symp. (1983) [Pubmed]
  29. De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation. Dodge, J.E., Ramsahoye, B.H., Wo, Z.G., Okano, M., Li, E. Gene (2002) [Pubmed]
  30. Gene therapy of RAG-2-/- mice: sustained correction of the immunodeficiency. Yates, F., Malassis-Séris, M., Stockholm, D., Bouneaud, C., Larousserie, F., Noguiez-Hellin, P., Danos, O., Kohn, D.B., Fischer, A., de Villartay, J.P., Cavazzana-Calvo, M. Blood (2002) [Pubmed]
  31. Construction of a defective retrovirus containing the human hypoxanthine phosphoribosyltransferase cDNA and its expression in cultured cells and mouse bone marrow. Chang, S.M., Wager-Smith, K., Tsao, T.Y., Henkel-Tigges, J., Vaishnav, S., Caskey, C.T. Mol. Cell. Biol. (1987) [Pubmed]
  32. T cell recognition of Moloney leukemia virus proteins. III. T cell proliferative responses against gp70 are associated with the production of a lymphokine inducing 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes. Ihle, J.N., Lee, J.C., Rebar, L. J. Immunol. (1981) [Pubmed]
  33. Rapid thymomas induced by Abelson murine leukemia virus. Cook, W.D. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  34. Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells. Tsukiyama, T., Niwa, O., Yokoro, K. Mol. Cell. Biol. (1989) [Pubmed]
  35. Immune response of BALB/c X DBA/2F1 mice to a tumor allograft during pyran copolymer-induced tumor enhancement. Schultz, R.M., Woods, W.A., Mohr, S.J., Chirigos, M.A. Cancer Res. (1976) [Pubmed]
  36. Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. Weiss, A., MacDonald, H.R., Cerottini, J.C., Brunner, K.T. J. Immunol. (1981) [Pubmed]
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