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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CEACAM4  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CGM7, CGM7_HUMAN, Carcinoembryonic antigen CGM7, Carcinoembryonic antigen-related cell adhesion molecule 4, NCA, ...
 
 
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High impact information on CEACAM4

  • NCA binding was disrupted by individual Cys substitutions at 13',14',16',17', and 19'. The inactivity of T13'C/T13'S may have been due to disturbance of the channel gate; I14'S and T16'S showed much better binding activity than their Cys counterparts, and the low activities of H17'C and R19'C were reversed by dithiothreitol [1].
  • In this study, we demonstrate that the closely related CEACAM4 and CEACAM7, which are also members of the CEA family, are not Opa receptors [2].
  • In 15 ALLs and seven B-cell lines which could be analyzed for CGM7 expression, the antigen was not detected [3].
  • The fluorine-18 labeled tyrosine derivatives were prepared by the displacement reaction of the ethyl and propyl tosylates with K[(18)F]/K2.2.2 in acetonitrile under no-carrier-added (NCA) conditions, followed by hydrolysis with 4N HCl [4].
  • Axonal transport of NSM to target organs is also in evidence and though NSM is seen in the NCA, it could not be detected inside the CA [5].

References

  1. Spontaneous Mobility of GABAA Receptor M2 Extracellular Half Relative to Noncompetitive Antagonist Action. Chen, L., Durkin, K.A., Casida, J.E. J. Biol. Chem. (2006) [Pubmed]
  2. Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. Popp, A., Dehio, C., Grunert, F., Meyer, T.F., Gray-Owen, S.D. Cell. Microbiol. (1999) [Pubmed]
  3. Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin. Hanenberg, H., Baumann, M., Quentin, I., Nagel, G., Grosse-Wilde, H., von Kleist, S., Göbel, U., Burdach, S., Grunert, F. Leukemia (1994) [Pubmed]
  4. Syntheses of F-18 labeled fluoroalkyltyrosine derivatives and their biological evaluation in rat bearing 9L tumor. Moon, B.S., Lee, T.S., Lee, K.C., An, G.I., Cheon, G.J., Lim, S.M., Choi, C.W., Chi, D.Y., Chun, K.S. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  5. Neuroendocrine organs of the lemon-butterfly, Papilio demoleus L. I. The corpora cardiaca-allata complex of the larva. Srivastava, K.P., Singh, H.H., Tiwari, R.K. Zeitschrift für mikroskopisch-anatomische Forschung. (1975) [Pubmed]
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