The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CEACAM7  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CEA, CGM2, Carcinoembryonic antigen CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CEACAM7


Psychiatry related information on CEACAM7


High impact information on CEACAM7

  • We have evaluated the potential of two different HLA-A2-restricted epitopes of CEA pulsed into dendritic cells in a therapeutic setting [6].
  • MV-Edm expressing CEA or hNIS elicited oncolytic effects in human HCC cell lines in vitro and in vivo, enabling the spread of the virus to be monitored in a noninvasive manner [7].
  • In the PPRs of the CGM2 gene, the DRA gene, and the TM30pl genes, which showed highly colon specific expression patterns, the consensus sequences of E boxes were commonly observed [8].
  • The CGM2 expression pattern along with its sequence homology to BGP suggests a similar tumor suppressor function for CGM2 [3].
  • Here we investigate the mRNAs of CD66a, CGM2, and NCA in 22 human colorectal adenomas and the respective normal mucosa specimens by Northern blots [9].

Chemical compound and disease context of CEACAM7


Biological context of CEACAM7

  • CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon, and both were absent from highly proliferating cells at the base of colonic crypts [1].
  • The focal expression of CD66a and CGM2 could be interpreted as due to a focal, incomplete, and abortive differentiation or, alternatively, as a consequence of genetic heterogeneity with foci of slow-proliferating subclones [4].
  • The reporter gene green fluorescent protein (GFP) driven by CEA promoter and human cytomegalovirus (CMV) promoter were relatively constructed and named plasmid pCEA-EGFP and pCMV-GFP respectively [15].
  • Transgene expression in HCC cell lines after infection with recombinant MV-Edm in vitro and in vivo was assessed by CEA concentration, (125)I-uptake, and (123)I-imaging studies [7].
  • The elderly and younger CCC groups had a similar sex ratio and a similar positive rate of carcinoembryonic antigen (CEA) and CA19-9 [16].

Anatomical context of CEACAM7


Associations of CEACAM7 with chemical compounds

  • In contrast, BGP and CGM2 mRNAs were restricted only to columnar cells at the upper third of the crypts and the luminal surface [19].
  • Thus CEA, a complex glycoprotein, was localised within the golgi apparatus, small apical cytoplasmic vesicles and mucous droplets in relatively well differentiated tumour cells [20].
  • Immunohistochemical findings revealed de novo emergence of CEA-producing carcinoma cells in the biopsy specimen taken after recurrence of pulmonary lesion during re-treatment of gefitinib, but revealed little or no CEA expression in the specimen obtained at first presentation [11].
  • The immunosensor was prepared by coating CEA/colloid Au/chitosan membrane at a screen-printed carbon electrode (SPCE) [21].
  • No correlation was found between expression of tissue CEA and steroid receptor status of the tumors [14].

Regulatory relationships of CEACAM7

  • Our data indicate a dysregulation of the three genes possibly with a common transcriptional control for CD66a and CGM2 and a different control for NCA [4].

Other interactions of CEACAM7

  • Complete or near-complete losses of the CD66a 3.9-kb mRNA and the CGM2 message were found in 13 of 22 and 15 of 22 of the tumors, respectively [9].
  • We have now carried out immunohistochemical expression studies on 35 different organs, using CEACAM6-specific (9A6) and CEACAM7-specific (BAC2) monoclonal antibodies [1].
  • In this study, we demonstrate that the closely related CEACAM4 and CEACAM7, which are also members of the CEA family, are not Opa receptors [22].
  • Positive selection using HEA-125 immunobeads was applied to blood samples before mRNA extraction, cDNA synthesis and a multiplex CEACAM5/CEACAM7 RT-PCR assay [2].
  • Analysis of these background-matched samples with DNA microarrays representing 3456 human genes resulted in the identification of candidate genes for PDC-specific markers, including those for AC133 and carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7) [23].

Analytical, diagnostic and therapeutic context of CEACAM7

  • IFN-gamma ELISPOT and (51)Cr-release assays showed that HLA-A2-restricted, CEA-specific CTL responses were augmented by combined dendritic cell vaccinations [6].
  • CEA levels in the sera were determined using an enzyme immunoassay, and CYFRA21-1 levels were determined using an enzyme chemiluminescent immunoassay [24].
  • The transcription activity of ectogenic human carcinoembryonic antigen (CEA) promoter in lung adenocarcinoma cells A549 was investigated for the further gene-targeting therapy [15].
  • The distinct specificity of CEA promoter in CEA high expression cells was regarded as a tool in selective gene therapy, but the transcription activity of ectogenic human CEA promoter was needed to increase in the future [15].
  • In another group in which cases were weakly positive for CEA (18% of the total) the prognosis was poor but chemotherapy produced significant improvement [25].


  1. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Schölzel, S., Zimmermann, W., Schwarzkopf, G., Grunert, F., Rogaczewski, B., Thompson, J. Am. J. Pathol. (2000) [Pubmed]
  2. Immunobead multiplex RT-PCR detection of carcinoembryonic genes expressing cells in the blood of colorectal cancer patients. Douard, R., Moutereau, S., Serru, V., Sales, J.P., Wind, P., Cugnenc, P.H., Vaubourdolle, M., Loric, S. Clin. Chem. Lab. Med. (2005) [Pubmed]
  3. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. Thompson, J., Seitz, M., Chastre, E., Ditter, M., Aldrian, C., Gespach, C., Zimmermann, W. Cancer Res. (1997) [Pubmed]
  4. Dysregulation of carcinoembryonic antigen group members CGM2, CD66a (biliary glycoprotein), and nonspecific cross-reacting antigen in colorectal carcinomas. Comparative analysis by northern blot and in situ hybridization. Nollau, P., Prall, F., Helmchen, U., Wagener, C., Neumaier, M. Am. J. Pathol. (1997) [Pubmed]
  5. Anti-idiotype antibody induced cellular immunity in mice transgenic for human carcinoembryonic antigen. Saha, A., Chatterjee, S.K., Foon, K.A., Bhattacharya-Chatterjee, M. Immunology (2006) [Pubmed]
  6. Therapy of established tumors in a novel murine model transgenic for human carcinoembryonic antigen and HLA-A2 with a combination of anti-idiotype vaccine and CTL peptides of carcinoembryonic antigen. Saha, A., Chatterjee, S.K., Foon, K.A., Celis, E., Bhattacharya-Chatterjee, M. Cancer Res. (2007) [Pubmed]
  7. Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. Blechacz, B., Splinter, P.L., Greiner, S., Myers, R., Peng, K.W., Federspiel, M.J., Russell, S.J., Larusso, N.F. Hepatology (2006) [Pubmed]
  8. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Suzuki, Y., Tsunoda, T., Sese, J., Taira, H., Mizushima-Sugano, J., Hata, H., Ota, T., Isogai, T., Tanaka, T., Nakamura, Y., Suyama, A., Sakaki, Y., Morishita, S., Okubo, K., Sugano, S. Genome Res. (2001) [Pubmed]
  9. Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Nollau, P., Scheller, H., Kona-Horstmann, M., Rohde, S., Hagenmüller, F., Wagener, C., Neumaier, M. Cancer Res. (1997) [Pubmed]
  10. Diagnostic accuracy of serum-carcinoembryonic antigen in recurrent colorectal cancer: a receiver operating characteristic curve analysis. Körner, H., Söreide, K., Stokkeland, P.J., Söreide, J.A. Ann. Surg. Oncol. (2007) [Pubmed]
  11. Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer. Hashimoto, N., Imaizumi, K., Honda, T., Kawabe, T., Nagasaka, T., Shimokata, K., Hasegawa, Y. Lung Cancer (2006) [Pubmed]
  12. Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing. Jung, H.S., Lee, S.W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Deglycosylation to obtain stable and homogeneous Pichia pastoris-expressed N-A1 domains of carcinoembryonic antigen. Sainz-Pastor, N., Tolner, B., Huhalov, A., Kogelberg, H., Lee, Y.C., Zhu, D., Begent, R.H., Chester, K.A. Int. J. Biol. Macromol. (2006) [Pubmed]
  14. Carcinoembryonic antigen. A possible predictor of recurrence in cystosarcoma phyllodes. Alberti, O., Brentani, M.M., Goes, J.C., Lemos, L.B., Torloni, H. Cancer (1986) [Pubmed]
  15. Transcription activity of ectogenic human carcinoembryonic antigen promoter in lung adenocarcinoma cells A549. Xiong, W., Fang, H., Xu, Y., Xiong, S., Cao, Y., Song, Q., Zeng, D., Zhang, H. J. Huazhong Univ. Sci. Technol. Med. Sci. (2006) [Pubmed]
  16. Hepatectomy for peripheral cholangiocarcinoma in elderly patients. Yeh, C.N., Jan, Y.Y., Chen, M.F. Ann. Surg. Oncol. (2006) [Pubmed]
  17. Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. Kinugasa, T., Kuroki, M., Takeo, H., Matsuo, Y., Ohshima, K., Yamashita, Y., Shirakusa, T., Matsuoka, Y. Int. J. Cancer (1998) [Pubmed]
  18. CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas. Thompson, J., Zimmermann, W., Nollau, P., Neumaier, M., Weber-Arden, J., Schrewe, H., Craig, I., Willcocks, T. J. Biol. Chem. (1994) [Pubmed]
  19. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. Frängsmyr, L., Baranov, V., Hammarström, S. Tumour Biol. (1999) [Pubmed]
  20. The ultrastructural immunohistochemistry of oncofoetal antigens in large bowel carcinomas. Haynes, W.D., Shertock, K.L., Skinner, J.M., Whitehead, R. Virchows Archiv. A, Pathological anatomy and histopathology. (1985) [Pubmed]
  21. A disposable electrochemical immunosensor for flow injection immunoassay of carcinoembryonic antigen. Wu, J., Tang, J., Dai, Z., Yan, F., Ju, H., Murr, N.E. Biosensors & bioelectronics. (2006) [Pubmed]
  22. Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. Popp, A., Dehio, C., Grunert, F., Meyer, T.F., Gray-Owen, S.D. Cell. Microbiol. (1999) [Pubmed]
  23. Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. Yoshida, K., Ueno, S., Iwao, T., Yamasaki, S., Tsuchida, A., Ohmine, K., Ohki, R., Choi, Y.L., Koinuma, K., Wada, T., Ota, J., Yamashita, Y., Chayama, K., Sato, K., Mano, H. Cancer Sci. (2003) [Pubmed]
  24. Relationship between N-linked oligosaccharide chains of human serum immunoglobulin G and serum tumor markers with non-small cell lung cancer progression. Kanoh, Y., Ohara, T., Mashiko, T., Abe, T., Masuda, N., Akahoshi, T. Anticancer Res. (2006) [Pubmed]
  25. The clinical value of immunohistochemically demonstrable CEA in breast cancer: a possible method of selecting patients for adjuvant chemotherapy. Smith, S.R., Howell, A., Minawa, A., Morrison, J.M. Br. J. Cancer (1982) [Pubmed]
WikiGenes - Universities